5A3U
HIF prolyl hydroxylase 2 (PHD2/EGLN1) in complex with 6-(5-oxo-4-(1H- 1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0031418 | molecular_function | L-ascorbic acid binding |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| B | 0031418 | molecular_function | L-ascorbic acid binding |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| C | 0031418 | molecular_function | L-ascorbic acid binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN A 1420 |
| Chain | Residue |
| A | HIS313 |
| A | ASP315 |
| A | HIS374 |
| A | R8J1421 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE R8J A 1421 |
| Chain | Residue |
| A | ARG383 |
| A | TRP389 |
| A | MN1420 |
| A | TYR303 |
| A | HIS313 |
| A | ASP315 |
| A | ARG322 |
| A | HIS374 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN B 1405 |
| Chain | Residue |
| B | HIS313 |
| B | ASP315 |
| B | HIS374 |
| B | R8J1406 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE R8J B 1406 |
| Chain | Residue |
| B | TYR303 |
| B | HIS313 |
| B | ASP315 |
| B | ARG322 |
| B | HIS374 |
| B | ARG383 |
| B | TRP389 |
| B | MN1405 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN C 1406 |
| Chain | Residue |
| C | HIS313 |
| C | ASP315 |
| C | HIS374 |
| C | R8J1407 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE R8J C 1407 |
| Chain | Residue |
| C | TYR303 |
| C | HIS313 |
| C | ASP315 |
| C | ARG322 |
| C | ILE327 |
| C | ARG383 |
| C | TRP389 |
| C | MN1406 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 303 |
| Details | Domain: {"description":"Fe2OG dioxygenase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16782814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19604478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28594552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2G19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V18","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19604478","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 15 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"21601578","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
