5A3B

Crystal structure of the ADP-ribosylating sirtuin (SirTM) from Streptococcus pyogenes in complex with ADP-ribose

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	SIR2 FAMILY PROTEIN	polymer	303	35156.6	1	UniProt (Q1JGN6) In PDB	STREPTOCOCCUS PYOGENES	ADP-RIBOSYLATING SIRTUIN, SIRTM
2	A	GLYCINE	non-polymer		75.1	2	Chemie (GLY)
3	A	ALANINE	non-polymer		89.1	1	Chemie (ALA)
4	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5	A	ADENOSINE-5-DIPHOSPHORIBOSE	non-polymer		559.3	1	Chemie (APR)
6	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
7		water	water		18.0	248	Chemie (HOH)

Sequence modifications

A: 1 - 293 (UniProt: Q1JGN6)

PDB	External Database	Details
Met -9	-	expression tag
Gly -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35156.6
Non-Polymers*	Number of molecules	6
	Total formula weight	926.0
All*	Total formula weight	36082.6

*Water molecules are not included.