5A2Q
Structure of the HCV IRES bound to the human ribosome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (2) | 18S RRNA | polymer | 1868 | 602432.6 | 1 | GenBank (337376) | HOMO SAPIENS (HUMAN) | |
| 2 | B (3) | HCV IRES | polymer | 257 | 82915.0 | 1 | HEPATITIS C VIRUS | ||
| 3 | C (A) | RIBOSOMAL PROTEIN US2 | polymer | 295 | 32883.9 | 1 | UniProt (P08865) Pfam (PF00318) Pfam (PF16122) | HOMO SAPIENS (HUMAN) | |
| 4 | D (B) | RIBOSOMAL PROTEIN ES1 | polymer | 264 | 30002.1 | 1 | UniProt (Q6NXR8) Pfam (PF01015) UniProt (by SIFTS) (P61247) | HOMO SAPIENS (HUMAN) | |
| 5 | E (C) | RIBOSOMAL PROTEIN US5 | polymer | 293 | 31376.5 | 1 | UniProt (P15880) Pfam (PF00333) Pfam (PF03719) | HOMO SAPIENS (HUMAN) | |
| 6 | F (D) | RIBOSOMAL PROTEIN US3 | polymer | 243 | 26729.4 | 1 | UniProt (P23396) Pfam (PF07650) Pfam (PF00189) | HOMO SAPIENS (HUMAN) | |
| 7 | G (E) | RIBOSOMAL PROTEIN ES4 | polymer | 263 | 29654.9 | 1 | UniProt (P62701) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121) Pfam (PF08071) | HOMO SAPIENS (HUMAN) | |
| 8 | H (F) | RIBOSOMAL PROTEIN US7 | polymer | 204 | 22913.5 | 1 | UniProt (P46782) Pfam (PF00177) | HOMO SAPIENS (HUMAN) | |
| 9 | I (G) | RIBOSOMAL PROTEIN ES6 | polymer | 249 | 28779.9 | 1 | UniProt (P62753) Pfam (PF01092) | HOMO SAPIENS (HUMAN) | |
| 10 | J (H) | RIBOSOMAL PROTEIN ES7 | polymer | 194 | 22168.9 | 1 | UniProt (P62081) Pfam (PF01251) | HOMO SAPIENS (HUMAN) | |
| 11 | K (I) | RIBOSOMAL PROTEIN ES8 | polymer | 208 | 24263.4 | 1 | UniProt (P62241) Pfam (PF01201) | HOMO SAPIENS (HUMAN) | |
| 12 | L (J) | RIBOSOMAL PROTEIN US4 | polymer | 194 | 22641.6 | 1 | UniProt (P46781) Pfam (PF00163) Pfam (PF01479) | HOMO SAPIENS (HUMAN) | |
| 13 | M (K) | RIBOSOMAL PROTEIN ES10 | polymer | 165 | 18933.8 | 1 | UniProt (P46783) Pfam (PF03501) | HOMO SAPIENS (HUMAN) | |
| 14 | N (L) | RIBOSOMAL PROTEIN US17 | polymer | 158 | 18468.8 | 1 | UniProt (P62280) Pfam (PF16205) Pfam (PF00366) | HOMO SAPIENS (HUMAN) | |
| 15 | O (M) | RIBOSOMAL PROTEIN ES12 | polymer | 132 | 14539.0 | 1 | UniProt (P25398) Pfam (PF01248) | HOMO SAPIENS (HUMAN) | |
| 16 | P (N) | RIBOSOMAL PROTEIN US15 | polymer | 151 | 17259.4 | 1 | UniProt (P62277) Pfam (PF08069) Pfam (PF00312) | HOMO SAPIENS (HUMAN) | |
| 17 | Q (O) | RIBOSOMAL PROTEIN US11 | polymer | 151 | 16302.8 | 1 | UniProt (P62263) Pfam (PF00411) | HOMO SAPIENS (HUMAN) | |
| 18 | R (P) | RIBOSOMAL PROTEIN US19 | polymer | 145 | 17076.2 | 1 | UniProt (P62841) Pfam (PF00203) | HOMO SAPIENS (HUMAN) | |
| 19 | S (Q) | RIBOSOMAL PROTEIN US9 | polymer | 146 | 16477.4 | 1 | UniProt (P62249) Pfam (PF00380) | HOMO SAPIENS (HUMAN) | |
| 20 | T (R) | RIBOSOMAL PROTEIN ES17 | polymer | 135 | 15578.2 | 1 | UniProt (P08708) Pfam (PF00833) | HOMO SAPIENS (HUMAN) | |
| 21 | U (S) | RIBOSOMAL PROTEIN US13 | polymer | 152 | 17759.8 | 1 | UniProt (P62269) Pfam (PF00416) | HOMO SAPIENS (HUMAN) | |
| 22 | V (T) | RIBOSOMAL PROTEIN ES19 | polymer | 146 | 16178.6 | 1 | UniProt (P39019) Pfam (PF01090) | HOMO SAPIENS (HUMAN) | |
| 23 | W (U) | RIBOSOMAL PROTEIN US10 | polymer | 119 | 13398.8 | 1 | UniProt (P60866) Pfam (PF00338) | HOMO SAPIENS (HUMAN) | |
| 24 | X (V) | RIBOSOMAL PROTEIN ES21 | polymer | 83 | 9124.4 | 1 | UniProt (P63220) Pfam (PF01249) | HOMO SAPIENS (HUMAN) | |
| 25 | Y (W) | RIBOSOMAL PROTEIN US8 | polymer | 130 | 14865.6 | 1 | UniProt (P62244) Pfam (PF00410) | HOMO SAPIENS (HUMAN) | |
| 26 | Z (X) | RIBOSOMAL PROTEIN US12 | polymer | 143 | 15844.7 | 1 | UniProt (P62266) Pfam (PF00164) | HOMO SAPIENS (HUMAN) | |
| 27 | AA (Y) | RIBOSOMAL PROTEIN ES24 | polymer | 130 | 15107.9 | 1 | UniProt (P62847) Pfam (PF01282) | HOMO SAPIENS (HUMAN) | |
| 28 | BA (Z) | RIBOSOMAL PROTEIN ES25 | polymer | 125 | 13776.2 | 1 | UniProt (P62851) Pfam (PF03297) | HOMO SAPIENS (HUMAN) | |
| 29 | CA (a) | RIBOSOMAL PROTEIN ES26 | polymer | 101 | 11673.8 | 1 | UniProt (P62854) Pfam (PF01283) | HOMO SAPIENS (HUMAN) | |
| 30 | DA (b) | RIBOSOMAL PROTEIN ES27 | polymer | 82 | 9210.8 | 1 | UniProt (P42677) Pfam (PF01667) | HOMO SAPIENS (HUMAN) | |
| 31 | EA (c) | RIBOSOMAL PROTEIN ES28 | polymer | 61 | 6878.9 | 1 | UniProt (P62857) Pfam (PF01200) | HOMO SAPIENS (HUMAN) | |
| 32 | FA (d) | RIBOSOMAL PROTEIN US14 | polymer | 55 | 6559.6 | 1 | UniProt (P62273) Pfam (PF00253) | HOMO SAPIENS (HUMAN) | |
| 33 | GA (e) | RIBOSOMAL PROTEIN ES30 | polymer | 56 | 6302.5 | 1 | UniProt (P62861) Pfam (PF04758) | HOMO SAPIENS (HUMAN) | |
| 34 | HA (f) | RIBOSOMAL PROTEIN ES31 | polymer | 72 | 8453.1 | 1 | UniProt (Q5RKT7) Pfam (PF01599) UniProt (by SIFTS) (P62979) | HOMO SAPIENS (HUMAN) | |
| 35 | IA (g) | RIBOSOMAL PROTEIN RACK1 | polymer | 315 | 34857.4 | 1 | UniProt (P63244) Pfam (PF00400) | HOMO SAPIENS (HUMAN) | |
| 36 | JA (h) | RIBOSOMAL PROTEIN EL41 | polymer | 24 | 3342.3 | 1 | UniProt (P62945) Pfam (PF05162) | HOMO SAPIENS (HUMAN) | |
| 37 | KA (r) | RIBOSOMAL PROTEIN EL19 | polymer | 13 | 1709.0 | 1 | UniProt (P84098) | HOMO SAPIENS (HUMAN) | |
| 38 | LA (w) | RIBOSOMAL PROTEIN EL24 | polymer | 62 | 6481.7 | 1 | UniProt (P83731) | HOMO SAPIENS (HUMAN) | |
| 39 | AB, AC, AD, AE, BB... (2) | MAGNESIUM ION | non-polymer | 24.3 | 98 | Chemie (MG) | |||
| 40 | GE, HE, IE (a, d, f) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 41 | JE, KE, LE (2, C, e) | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
G: 1 - 249 (UniProt: P62753)
a: 2 - 102 (UniProt: P62854)
w: 65 - 78 (PDB: 5A2Q)
w: 79 - 126 (UniProt: P83731)
| PDB | External Database | Details |
|---|---|---|
| Arg 221 | Lys 221 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Val 78 | Ala 78 | conflict |
w: 79 - 126 (UniProt: P83731)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 38 |
| Total formula weight | 1302922.2 | |
| Non-Polymers* | Number of molecules | 101 |
| Total formula weight | 2578.1 | |
| All* | Total formula weight | 1305500.4 |
