5A1P
Crystal structure of cytochrome P450 3A4 bound to progesterone and citrate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CYTOCHROME P450 3A4 | polymer | 487 | 55757.8 | 1 | UniProt (P08684) Pfam (PF00067) | HOMO SAPIENS (HUMAN) | 1,8-CINEOLE 2-EXO-MONOOXYGENASE, ALBENDAZOLE MONOOXYGENASE, ALBENDAZOLE SULFOXIDASE, CYPIIIA3, CYPIIIA4, CYTOCHROME P450 3A3, CYTOCHROME P450 HLP, CYTOCHROME P450 NF-25, CYTOCHROME P450-PCN1, NIFEDIPINE OXIDASE, QUININE 3-MONOOXYGENASE, TAUROCHENODEOXYCHOLATE 6-ALPHA-HYDROXYLASE |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C (A) | PROGESTERONE | non-polymer | 314.5 | 1 | Chemie (STR) PubChem (16219863) PubChem (16401562) PubChem (16757724) PubChem (18635648) PubChem (4920) PubChem (23615931) PubChem (5994) PubChem (71200542) PubChem (44135692) PubChem (44275133) PubChem (44279092) PubChem (92940) PubChem (54269928) PubChem (57526392) PubChem (58483135) PubChem (58766357) PubChem (58872617) PubChem (1807216) PubChem (1807215) PubChem (1807214) PubChem (70865784) PubChem (70987742) PubChem (70987859) PubChem (638017) PubChem (657254) PubChem (1274466) PubChem (1201516) PubChem (5320716) PubChem (6603959) PubChem (7004693) PubChem (6576615) PubChem (7048588) PubChem (117072378) PubChem (118670641) PubChem (7059604) PubChem (7059605) PubChem (7059606) PubChem (7092664) PubChem (7092665) PubChem (7092666) PubChem (11869416) PubChem (144033743) PubChem (9948776) PubChem (123410055) PubChem (12303982) PubChem (12303979) PubChem (11869413) PubChem (11869414) PubChem (11869415) PubChem (11876098) PubChem (11876099) PubChem (11876100) PubChem (12303971) PubChem (12303981) PubChem (12303986) PubChem (12303989) PubChem (12303992) PubChem (170068371) PubChem (129010392) PubChem (134688829) PubChem (135189961) PubChem (135190011) PubChem (135249041) PubChem (142168519) PubChem (142402781) PubChem (145130068) PubChem (163070289) PubChem (163070290) PubChem (163070291) PubChem (163070292) | |||
| 4 | D (A) | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) PubChem (311) | |||
| 5 | E (A) | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A: 23 - 503 (UniProt: P08684)
| PDB | External Database | Details |
|---|---|---|
| Met 21 | - | expression tag |
| Ala 22 | - | expression tag |
| His 504 | - | expression tag |
| His 505 | - | expression tag |
| His 506 | - | expression tag |
| His 507 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 55757.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1123.1 | |
| All* | Total formula weight | 56880.9 |
