5A0C
Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NEUTROPHIL ELASTASE | polymer | 218 | 23319.0 | 2 | UniProt (P08246) Pfam (PF00089) | HOMO SAPIENS (HUMAN) | BONE MARROW SERINE PROTEASE, ELASTASE-2, HUMAN LEUKOCYTE EL ASTASE, HLE, MEDULLASIN, PMN ELASTASE, ELASTASE, HLE, MEDULIASIN, PMN ELASTASE |
| 2 | C, E (C, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 2 | In PDB GlyTouCan (G21290RB) | |||
| 3 | D, F (D, F) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 2 | In PDB GlyTouCan (G86851RC) | |||
| 4 | G, J (A, B) | (6S)-6-(4-cyano-2-methylsulfonyl-phenyl)-4-methyl-2-oxidanylidene-3-[3-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-5-carbonitrile | non-polymer | 460.4 | 2 | Chemie (JJV) | |||
| 5 | H, K (A, B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
| 6 | I (A) | 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL | non-polymer | 458.5 | 1 | Chemie (XPE) | |||
| 7 | L, M (A, B) | water | water | 18.0 | 334 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 46638.0 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1875.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1769.9 | |
| All* | Total formula weight | 50283.6 |
