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5A0C

Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001878biological_processresponse to yeast
A0002020molecular_functionprotease binding
A0002438biological_processacute inflammatory response to antigenic stimulus
A0002523biological_processleukocyte migration involved in inflammatory response
A0002812biological_processbiosynthetic process of antibacterial peptides active against Gram-negative bacteria
A0003714molecular_functiontranscription corepressor activity
A0004175molecular_functionendopeptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006508biological_processproteolysis
A0006874biological_processintracellular calcium ion homeostasis
A0006909biological_processphagocytosis
A0008201molecular_functionheparin binding
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0009411biological_processresponse to UV
A0009986cellular_componentcell surface
A0017053cellular_componenttranscription repressor complex
A0019955molecular_functioncytokine binding
A0022617biological_processextracellular matrix disassembly
A0030141cellular_componentsecretory granule
A0030163biological_processprotein catabolic process
A0031410cellular_componentcytoplasmic vesicle
A0032496biological_processresponse to lipopolysaccharide
A0032682biological_processnegative regulation of chemokine production
A0032717biological_processnegative regulation of interleukin-8 production
A0032757biological_processpositive regulation of interleukin-8 production
A0035578cellular_componentazurophil granule lumen
A0035580cellular_componentspecific granule lumen
A0042742biological_processdefense response to bacterium
A0043406biological_processpositive regulation of MAP kinase activity
A0045335cellular_componentphagocytic vesicle
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0050728biological_processnegative regulation of inflammatory response
A0050778biological_processpositive regulation of immune response
A0050832biological_processdefense response to fungus
A0050900biological_processleukocyte migration
A0050922biological_processnegative regulation of chemotaxis
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0070269biological_processpyroptotic inflammatory response
A0070945biological_processneutrophil-mediated killing of gram-negative bacterium
A0070947biological_processneutrophil-mediated killing of fungus
A1903238biological_processpositive regulation of leukocyte tethering or rolling
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001878biological_processresponse to yeast
B0002020molecular_functionprotease binding
B0002438biological_processacute inflammatory response to antigenic stimulus
B0002523biological_processleukocyte migration involved in inflammatory response
B0002812biological_processbiosynthetic process of antibacterial peptides active against Gram-negative bacteria
B0003714molecular_functiontranscription corepressor activity
B0004175molecular_functionendopeptidase activity
B0004252molecular_functionserine-type endopeptidase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006508biological_processproteolysis
B0006874biological_processintracellular calcium ion homeostasis
B0006909biological_processphagocytosis
B0008201molecular_functionheparin binding
B0008233molecular_functionpeptidase activity
B0008236molecular_functionserine-type peptidase activity
B0009411biological_processresponse to UV
B0009986cellular_componentcell surface
B0017053cellular_componenttranscription repressor complex
B0019955molecular_functioncytokine binding
B0022617biological_processextracellular matrix disassembly
B0030141cellular_componentsecretory granule
B0030163biological_processprotein catabolic process
B0031410cellular_componentcytoplasmic vesicle
B0032496biological_processresponse to lipopolysaccharide
B0032682biological_processnegative regulation of chemokine production
B0032717biological_processnegative regulation of interleukin-8 production
B0032757biological_processpositive regulation of interleukin-8 production
B0035578cellular_componentazurophil granule lumen
B0035580cellular_componentspecific granule lumen
B0042742biological_processdefense response to bacterium
B0043406biological_processpositive regulation of MAP kinase activity
B0045335cellular_componentphagocytic vesicle
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0050728biological_processnegative regulation of inflammatory response
B0050778biological_processpositive regulation of immune response
B0050832biological_processdefense response to fungus
B0050900biological_processleukocyte migration
B0050922biological_processnegative regulation of chemotaxis
B0062023cellular_componentcollagen-containing extracellular matrix
B0070062cellular_componentextracellular exosome
B0070269biological_processpyroptotic inflammatory response
B0070945biological_processneutrophil-mediated killing of gram-negative bacterium
B0070947biological_processneutrophil-mediated killing of fungus
B1903238biological_processpositive regulation of leukocyte tethering or rolling
Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. MSAAHC
ChainResidueDetails
AMET53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. GVcfGDSGSPLV
ChainResidueDetails
AGLY196-VAL207

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: Charge relay system => ECO:0000269|PubMed:2911584
ChainResidueDetails
AHIS57
AASP106
ASER202
BHIS57
BASP106
BSER202

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN76
BASN76

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:26274980, ECO:0000269|PubMed:3550808
ChainResidueDetails
AASN113
BASN113

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:3550808
ChainResidueDetails
AASN163
BASN163

226707

PDB entries from 2024-10-30

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