5TWV
Cryo-EM structure of the pancreatic ATP-sensitive K+ channel SUR1/Kir6.2 in the presence of ATP and glibenclamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | ATP-sensitive inward rectifier potassium channel 11 | polymer | 390 | 43645.7 | 4 | Pfam (PF01007) Pfam (PF17655) UniProt (by SIFTS) (P70673) | Rattus norvegicus (Rat) | BIR, Inward rectifier K(+) channel Kir6.2, Potassium channel, inwardly rectifying subfamily J member 11 |
| 2 | B, D, F, H (B, D, F, H) | ATP-binding cassette sub-family C member 8 | polymer | 1590 | 178330.5 | 4 | UniProt (Q09427) Pfam (PF00664) Pfam (PF00005) | Cricetus cricetus (Black-bellied hamster) | Sulfonylurea receptor 1, SUR1 |
| 3 | I, J, K, L (A, C, E, G) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (ATP) |
Sequence modifications
B, D, F, H: 1 - 1582 (UniProt: Q09427)
| PDB | External Database | Details |
|---|---|---|
| Asp -7 | - | expression tag |
| Tyr -6 | - | expression tag |
| Lys -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Lys 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 887904.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2028.7 | |
| All* | Total formula weight | 889933.7 |
