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5TWV

Cryo-EM structure of the pancreatic ATP-sensitive K+ channel SUR1/Kir6.2 in the presence of ATP and glibenclamide

Functional Information from GO Data
ChainGOidnamespacecontents
A0001508biological_processaction potential
A0001666biological_processresponse to hypoxia
A0001669cellular_componentacrosomal vesicle
A0002931biological_processresponse to ischemia
A0003229biological_processventricular cardiac muscle tissue development
A0005242molecular_functioninward rectifier potassium channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005635cellular_componentnuclear envelope
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005886cellular_componentplasma membrane
A0006006biological_processglucose metabolic process
A0006813biological_processpotassium ion transport
A0006915biological_processapoptotic process
A0006950biological_processresponse to stress
A0008282cellular_componentinward rectifying potassium channel
A0008340biological_processdetermination of adult lifespan
A0009410biological_processresponse to xenobiotic stimulus
A0014704cellular_componentintercalated disc
A0015272molecular_functionATP-activated inward rectifier potassium channel activity
A0016020cellular_componentmembrane
A0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
A0030315cellular_componentT-tubule
A0030506molecular_functionankyrin binding
A0030673cellular_componentaxolemma
A0031072molecular_functionheat shock protein binding
A0031669biological_processcellular response to nutrient levels
A0032355biological_processresponse to estradiol
A0033198biological_processresponse to ATP
A0033574biological_processresponse to testosterone
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0034765biological_processregulation of monoatomic ion transmembrane transport
A0042383cellular_componentsarcolemma
A0042391biological_processregulation of membrane potential
A0042734cellular_componentpresynaptic membrane
A0043025cellular_componentneuronal cell body
A0044325molecular_functiontransmembrane transporter binding
A0046676biological_processnegative regulation of insulin secretion
A0050796biological_processregulation of insulin secretion
A0050877biological_processnervous system process
A0061762biological_processCAMKK-AMPK signaling cascade
A0070852cellular_componentcell body fiber
A0071316biological_processcellular response to nicotine
A0071333biological_processcellular response to glucose stimulus
A0071356biological_processcellular response to tumor necrosis factor
A0071805biological_processpotassium ion transmembrane transport
A0098662biological_processinorganic cation transmembrane transport
A0098978cellular_componentglutamatergic synapse
A0099505biological_processregulation of presynaptic membrane potential
A0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A1903078biological_processpositive regulation of protein localization to plasma membrane
A1904638biological_processresponse to resveratrol
A1990573biological_processpotassium ion import across plasma membrane
B0005267molecular_functionpotassium channel activity
B0005524molecular_functionATP binding
B0005886cellular_componentplasma membrane
B0006813biological_processpotassium ion transport
B0008281molecular_functionsulfonylurea receptor activity
B0016020cellular_componentmembrane
B0016887molecular_functionATP hydrolysis activity
B0042626molecular_functionATPase-coupled transmembrane transporter activity
B0055085biological_processtransmembrane transport
B0071805biological_processpotassium ion transmembrane transport
B0140359molecular_functionABC-type transporter activity
C0001508biological_processaction potential
C0001666biological_processresponse to hypoxia
C0001669cellular_componentacrosomal vesicle
C0002931biological_processresponse to ischemia
C0003229biological_processventricular cardiac muscle tissue development
C0005242molecular_functioninward rectifier potassium channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005635cellular_componentnuclear envelope
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005886cellular_componentplasma membrane
C0006006biological_processglucose metabolic process
C0006813biological_processpotassium ion transport
C0006915biological_processapoptotic process
C0006950biological_processresponse to stress
C0008282cellular_componentinward rectifying potassium channel
C0008340biological_processdetermination of adult lifespan
C0009410biological_processresponse to xenobiotic stimulus
C0014704cellular_componentintercalated disc
C0015272molecular_functionATP-activated inward rectifier potassium channel activity
C0016020cellular_componentmembrane
C0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
C0030315cellular_componentT-tubule
C0030506molecular_functionankyrin binding
C0030673cellular_componentaxolemma
C0031072molecular_functionheat shock protein binding
C0031669biological_processcellular response to nutrient levels
C0032355biological_processresponse to estradiol
C0033198biological_processresponse to ATP
C0033574biological_processresponse to testosterone
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0034765biological_processregulation of monoatomic ion transmembrane transport
C0042383cellular_componentsarcolemma
C0042391biological_processregulation of membrane potential
C0042734cellular_componentpresynaptic membrane
C0043025cellular_componentneuronal cell body
C0044325molecular_functiontransmembrane transporter binding
C0046676biological_processnegative regulation of insulin secretion
C0050796biological_processregulation of insulin secretion
C0050877biological_processnervous system process
C0061762biological_processCAMKK-AMPK signaling cascade
C0070852cellular_componentcell body fiber
C0071316biological_processcellular response to nicotine
C0071333biological_processcellular response to glucose stimulus
C0071356biological_processcellular response to tumor necrosis factor
C0071805biological_processpotassium ion transmembrane transport
C0098662biological_processinorganic cation transmembrane transport
C0098978cellular_componentglutamatergic synapse
C0099505biological_processregulation of presynaptic membrane potential
C0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C1903078biological_processpositive regulation of protein localization to plasma membrane
C1904638biological_processresponse to resveratrol
C1990573biological_processpotassium ion import across plasma membrane
D0005267molecular_functionpotassium channel activity
D0005524molecular_functionATP binding
D0005886cellular_componentplasma membrane
D0006813biological_processpotassium ion transport
D0008281molecular_functionsulfonylurea receptor activity
D0016020cellular_componentmembrane
D0016887molecular_functionATP hydrolysis activity
D0042626molecular_functionATPase-coupled transmembrane transporter activity
D0055085biological_processtransmembrane transport
D0071805biological_processpotassium ion transmembrane transport
D0140359molecular_functionABC-type transporter activity
E0001508biological_processaction potential
E0001666biological_processresponse to hypoxia
E0001669cellular_componentacrosomal vesicle
E0002931biological_processresponse to ischemia
E0003229biological_processventricular cardiac muscle tissue development
E0005242molecular_functioninward rectifier potassium channel activity
E0005249molecular_functionvoltage-gated potassium channel activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005635cellular_componentnuclear envelope
E0005737cellular_componentcytoplasm
E0005768cellular_componentendosome
E0005886cellular_componentplasma membrane
E0006006biological_processglucose metabolic process
E0006813biological_processpotassium ion transport
E0006915biological_processapoptotic process
E0006950biological_processresponse to stress
E0008282cellular_componentinward rectifying potassium channel
E0008340biological_processdetermination of adult lifespan
E0009410biological_processresponse to xenobiotic stimulus
E0014704cellular_componentintercalated disc
E0015272molecular_functionATP-activated inward rectifier potassium channel activity
E0016020cellular_componentmembrane
E0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
E0030315cellular_componentT-tubule
E0030506molecular_functionankyrin binding
E0030673cellular_componentaxolemma
E0031072molecular_functionheat shock protein binding
E0031669biological_processcellular response to nutrient levels
E0032355biological_processresponse to estradiol
E0033198biological_processresponse to ATP
E0033574biological_processresponse to testosterone
E0034220biological_processmonoatomic ion transmembrane transport
E0034702cellular_componentmonoatomic ion channel complex
E0034765biological_processregulation of monoatomic ion transmembrane transport
E0042383cellular_componentsarcolemma
E0042391biological_processregulation of membrane potential
E0042734cellular_componentpresynaptic membrane
E0043025cellular_componentneuronal cell body
E0044325molecular_functiontransmembrane transporter binding
E0046676biological_processnegative regulation of insulin secretion
E0050796biological_processregulation of insulin secretion
E0050877biological_processnervous system process
E0061762biological_processCAMKK-AMPK signaling cascade
E0070852cellular_componentcell body fiber
E0071316biological_processcellular response to nicotine
E0071333biological_processcellular response to glucose stimulus
E0071356biological_processcellular response to tumor necrosis factor
E0071805biological_processpotassium ion transmembrane transport
E0098662biological_processinorganic cation transmembrane transport
E0098978cellular_componentglutamatergic synapse
E0099505biological_processregulation of presynaptic membrane potential
E0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
E1903078biological_processpositive regulation of protein localization to plasma membrane
E1904638biological_processresponse to resveratrol
E1990573biological_processpotassium ion import across plasma membrane
F0005267molecular_functionpotassium channel activity
F0005524molecular_functionATP binding
F0005886cellular_componentplasma membrane
F0006813biological_processpotassium ion transport
F0008281molecular_functionsulfonylurea receptor activity
F0016020cellular_componentmembrane
F0016887molecular_functionATP hydrolysis activity
F0042626molecular_functionATPase-coupled transmembrane transporter activity
F0055085biological_processtransmembrane transport
F0071805biological_processpotassium ion transmembrane transport
F0140359molecular_functionABC-type transporter activity
G0001508biological_processaction potential
G0001666biological_processresponse to hypoxia
G0001669cellular_componentacrosomal vesicle
G0002931biological_processresponse to ischemia
G0003229biological_processventricular cardiac muscle tissue development
G0005242molecular_functioninward rectifier potassium channel activity
G0005249molecular_functionvoltage-gated potassium channel activity
G0005515molecular_functionprotein binding
G0005524molecular_functionATP binding
G0005635cellular_componentnuclear envelope
G0005737cellular_componentcytoplasm
G0005768cellular_componentendosome
G0005886cellular_componentplasma membrane
G0006006biological_processglucose metabolic process
G0006813biological_processpotassium ion transport
G0006915biological_processapoptotic process
G0006950biological_processresponse to stress
G0008282cellular_componentinward rectifying potassium channel
G0008340biological_processdetermination of adult lifespan
G0009410biological_processresponse to xenobiotic stimulus
G0014704cellular_componentintercalated disc
G0015272molecular_functionATP-activated inward rectifier potassium channel activity
G0016020cellular_componentmembrane
G0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
G0030315cellular_componentT-tubule
G0030506molecular_functionankyrin binding
G0030673cellular_componentaxolemma
G0031072molecular_functionheat shock protein binding
G0031669biological_processcellular response to nutrient levels
G0032355biological_processresponse to estradiol
G0033198biological_processresponse to ATP
G0033574biological_processresponse to testosterone
G0034220biological_processmonoatomic ion transmembrane transport
G0034702cellular_componentmonoatomic ion channel complex
G0034765biological_processregulation of monoatomic ion transmembrane transport
G0042383cellular_componentsarcolemma
G0042391biological_processregulation of membrane potential
G0042734cellular_componentpresynaptic membrane
G0043025cellular_componentneuronal cell body
G0044325molecular_functiontransmembrane transporter binding
G0046676biological_processnegative regulation of insulin secretion
G0050796biological_processregulation of insulin secretion
G0050877biological_processnervous system process
G0061762biological_processCAMKK-AMPK signaling cascade
G0070852cellular_componentcell body fiber
G0071316biological_processcellular response to nicotine
G0071333biological_processcellular response to glucose stimulus
G0071356biological_processcellular response to tumor necrosis factor
G0071805biological_processpotassium ion transmembrane transport
G0098662biological_processinorganic cation transmembrane transport
G0098978cellular_componentglutamatergic synapse
G0099505biological_processregulation of presynaptic membrane potential
G0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
G1903078biological_processpositive regulation of protein localization to plasma membrane
G1904638biological_processresponse to resveratrol
G1990573biological_processpotassium ion import across plasma membrane
H0005267molecular_functionpotassium channel activity
H0005524molecular_functionATP binding
H0005886cellular_componentplasma membrane
H0006813biological_processpotassium ion transport
H0008281molecular_functionsulfonylurea receptor activity
H0016020cellular_componentmembrane
H0016887molecular_functionATP hydrolysis activity
H0042626molecular_functionATPase-coupled transmembrane transporter activity
H0055085biological_processtransmembrane transport
H0071805biological_processpotassium ion transmembrane transport
H0140359molecular_functionABC-type transporter activity
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue ATP A 401
ChainResidue
AASN48
AILE49
AARG50
CILE182
CPHE183
CLYS185
CLEU205
CPHE333
CGLY334

site_idAC2
Number of Residues9
Detailsbinding site for residue ATP C 401
ChainResidue
CASN48
CILE49
CARG50
EILE182
EPHE183
ELYS185
ELEU205
EPHE333
EGLY334

site_idAC3
Number of Residues9
Detailsbinding site for residue ATP E 401
ChainResidue
EASN48
EILE49
EARG50
GILE182
GPHE183
GLYS185
GLEU205
GPHE333
GGLY334

site_idAC4
Number of Residues9
Detailsbinding site for residue ATP G 401
ChainResidue
AILE182
APHE183
ALYS185
ALEU205
APHE333
AGLY334
GASN48
GILE49
GARG50

Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRISVARAL
ChainResidueDetails
BLEU830-LEU844
BPHE1482-PHE1496

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1160
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
AMET1-TRP68
DARG1274-SER1277
FMET1-VAL34
FGLY97-SER101
FVAL155-LEU167
FLEU1027-SER1073
FARG1274-SER1277
HMET1-VAL34
HGLY97-SER101
HVAL155-LEU167
HLEU1027-SER1073
AILE167-SER390
HARG1274-SER1277
CMET1-TRP68
CILE167-SER390
EMET1-TRP68
EILE167-SER390
GMET1-TRP68
GILE167-SER390
DLEU1027-SER1073

site_idSWS_FT_FI2
Number of Residues96
DetailsTRANSMEM: Helical; Name=M1 => ECO:0000250
ChainResidueDetails
APRO69-ILE93
CPRO69-ILE93
EPRO69-ILE93
GPRO69-ILE93

site_idSWS_FT_FI3
Number of Residues120
DetailsTOPO_DOM: Extracellular => ECO:0000250
ChainResidueDetails
AALA94-SER116
DVAL1299-LYS1582
FSER56-TRP75
FTYR123-LYS134
FTYR195-LEU311
FSER606-LEU1005
FVAL1299-LYS1582
HSER56-TRP75
HTYR123-LYS134
HTYR195-LEU311
HSER606-LEU1005
AARG136-LEU144
HVAL1299-LYS1582
CALA94-SER116
CARG136-LEU144
EALA94-SER116
EARG136-LEU144
GALA94-SER116
GARG136-LEU144
DSER606-LEU1005

site_idSWS_FT_FI4
Number of Residues44
DetailsINTRAMEM: Helical; Pore-forming; Name=H5 => ECO:0000250
ChainResidueDetails
APHE117-GLN128
CPHE117-GLN128
EPHE117-GLN128
GPHE117-GLN128

site_idSWS_FT_FI5
Number of Residues24
DetailsINTRAMEM: Pore-forming => ECO:0000250
ChainResidueDetails
AVAL129-GLY135
CVAL129-GLY135
EVAL129-GLY135
GVAL129-GLY135

site_idSWS_FT_FI6
Number of Residues84
DetailsTRANSMEM: Helical; Name=M2 => ECO:0000250
ChainResidueDetails
AALA145-CYS166
CALA145-CYS166
EALA145-CYS166
GALA145-CYS166

site_idSWS_FT_FI7
Number of Residues4
DetailsSITE: Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium => ECO:0000250
ChainResidueDetails
AASN160
CASN160
EASN160
GASN160

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by MAPK1 => ECO:0000250|UniProtKB:Q14654
ChainResidueDetails
ATHR341
CTHR341
ETHR341
GTHR341

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine; by MAPK1 => ECO:0000250|UniProtKB:Q14654
ChainResidueDetails
ASER385
FLEU456-VAL458
FVAL563-HIS584
FVAL1160
HHIS332-ALA355
HLEU456-VAL458
HVAL563-HIS584
HVAL1160
CSER385
ESER385
GSER385
DHIS332-ALA355
DLEU456-VAL458
DVAL563-HIS584
DVAL1160
FHIS332-ALA355

site_idSWS_FT_FI10
Number of Residues80
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
BTYR356-SER376
DTYR356-SER376
FTYR356-SER376
HTYR356-SER376

site_idSWS_FT_FI11
Number of Residues924
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
BTYR377-LEU434
FLYS480-SER541
FLYS1095-SER1138
FPHE1182-MET1252
HTYR377-LEU434
HLYS480-SER541
HLYS1095-SER1138
HPHE1182-MET1252
BLYS480-SER541
BLYS1095-SER1138
BPHE1182-MET1252
DTYR377-LEU434
DLYS480-SER541
DLYS1095-SER1138
DPHE1182-MET1252
FTYR377-LEU434

site_idSWS_FT_FI12
Number of Residues80
DetailsTRANSMEM: Helical; Name=8 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
BCYS435-ILE455
DCYS435-ILE455
FCYS435-ILE455
HCYS435-ILE455

site_idSWS_FT_FI13
Number of Residues80
DetailsTRANSMEM: Helical; Name=9 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
BSER459-THR479
DSER459-THR479
FSER459-THR479
HSER459-THR479

site_idSWS_FT_FI14
Number of Residues80
DetailsTRANSMEM: Helical; Name=10 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
BILE542-HIS562
DILE542-HIS562
FILE542-HIS562
HILE542-HIS562

site_idSWS_FT_FI15
Number of Residues80
DetailsTRANSMEM: Helical; Name=11 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
BILE585-VAL605
DILE585-VAL605
FILE585-VAL605
HILE585-VAL605

site_idSWS_FT_FI16
Number of Residues80
DetailsTRANSMEM: Helical; Name=12
ChainResidueDetails
BSER1006-VAL1026
DSER1006-VAL1026
FSER1006-VAL1026
HSER1006-VAL1026

site_idSWS_FT_FI17
Number of Residues80
DetailsTRANSMEM: Helical; Name=13 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
BLEU1074-ALA1094
DLEU1074-ALA1094
FLEU1074-ALA1094
HLEU1074-ALA1094

site_idSWS_FT_FI18
Number of Residues80
DetailsTRANSMEM: Helical; Name=14 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
BTHR1139-TYR1159
DTHR1139-TYR1159
FTHR1139-TYR1159
HTHR1139-TYR1159

site_idSWS_FT_FI19
Number of Residues80
DetailsTRANSMEM: Helical; Name=15 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
BTHR1161-TYR1181
DTHR1161-TYR1181
FTHR1161-TYR1181
HTHR1161-TYR1181

site_idSWS_FT_FI20
Number of Residues80
DetailsTRANSMEM: Helical; Name=16 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
BGLU1253-HIS1273
DGLU1253-HIS1273
FGLU1253-HIS1273
HGLU1253-HIS1273

site_idSWS_FT_FI21
Number of Residues80
DetailsTRANSMEM: Helical; Name=17
ChainResidueDetails
BALA1278-MET1298
DALA1278-MET1298
FALA1278-MET1298
HALA1278-MET1298

site_idSWS_FT_FI22
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434
ChainResidueDetails
BGLY713
BGLY1379
DGLY713
DGLY1379
FGLY713
FGLY1379
HGLY713
HGLY1379

site_idSWS_FT_FI23
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10506167, ECO:0000269|PubMed:8942641
ChainResidueDetails
BASN10
DASN10
FASN10
HASN10

site_idSWS_FT_FI24
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
BASN1050
DASN1050
FASN1050
HASN1050

219140

PDB entries from 2024-05-01

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