4ZZY
Structure of human PARP2 catalytic domain bound to an isoindolinone inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | POLY [ADP-RIBOSE] POLYMERASE 2 | polymer | 363 | 41102.3 | 1 | UniProt (Q9UGN5) Pfam (PF02877) Pfam (PF00644) | HOMO SAPIENS (HUMAN) | PARP-2, HPARP-2, ADP-RIBOSYLTRANSFERASE DIPHTHERIA TOXIN-LI KE 2, ARTD2, NAD(+) ADP-RIBOSYLTRANSFERASE 2, ADPRT-2, POLYADP-RIB OSE SYNTHASE 2, PADPRT-2, PARP-2, HPARP-2, ADP-RIBOSYLTRANSFERASE DIPHTHERIA TOXIN-LIKE 2, ARTD2, NAD(+) ADP-RIBOSYLTRANSFERASE 2, A DPRT-2, POLYADP- RIBOSE SYNTHASE 2, PADPRT-2, POLY ADP-RIBOSE POLY MERASE 2, POLY ADP-RIBOSE POLYMERASE 2 |
| 2 | B (A) | 2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide | non-polymer | 395.4 | 1 | Chemie (D7N) | |||
| 3 | C (A) | water | water | 18.0 | 80 | Chemie (HOH) |
Sequence modifications
A: 223 - 583 (UniProt: Q9UGN5)
| PDB | External Database | Details |
|---|---|---|
| Gly 221 | - | expression tag |
| Pro 222 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41102.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 395.4 | |
| All* | Total formula weight | 41497.7 |
