4ZZY

Structure of human PARP2 catalytic domain bound to an isoindolinone inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE D7N A 1584

Chain	Residue
A	SER328
A	ALA464
A	LYS469
A	SER470
A	TYR473
A	GLU558
A	ILE331
A	GLN332
A	HIS428
A	GLY429
A	GLY454
A	TYR455
A	TYR462
A	PHE463

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Functional Information from PROSITE/UniProt

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LLEANPKA

Chain	Residue	Details
A	LEU498-ALA505

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site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HgsrmSnwVgILSHG

Chain	Residue	Details
A	HIS428-GLY442

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: For poly [ADP-ribose] polymerase activity => ECO:0000305|PubMed:26704974, ECO:0000305|PubMed:30104678, ECO:0000305|PubMed:32028527

Chain	Residue	Details
A	GLU558

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:32028527, ECO:0007744|PDB:6TX3

Chain	Residue	Details
A	HIS428
A	GLY437
A	ARG444
A	SER470

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
A	SER226
A	SER232

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