4ZZH

SIRT1/Activator Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	NAD-dependent protein deacetylase sirtuin-1	polymer	356	40125.3	1	UniProt (Q96EB6) Pfam (PF02146)	Homo sapiens (Human)	hSIRT1,Regulatory protein SIR2 homolog 1,SIR2-like protein 1,hSIR2
2	B (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
3	C (A)	(4S)-N-[3-(1,3-oxazol-5-yl)phenyl]-7-[3-(trifluoromethyl)phenyl]-3,4-dihydro-1,4-methanopyrido[2,3-b][1,4]diazepine-5(2H)-carboxamide	non-polymer		491.5	1	Chemie (4TO)

Sequence modifications

A: 183 - 632 (UniProt: Q96EB6)

PDB	External Database	Details
Gly 633	-	expression tag
Gly 634	-	expression tag
Gly 635	-	expression tag
Ser 636	-	expression tag
Gly 637	-	expression tag
Gly 638	-	expression tag
Gly 639	-	expression tag
Ser 640	-	expression tag
Gln 641	-	expression tag
Tyr 642	-	expression tag
Leu 643	-	expression tag
Phe 644	-	expression tag
Leu 645	-	expression tag
Pro 646	-	expression tag
Pro 647	-	expression tag
Asn 648	-	expression tag
Arg 649	-	expression tag
Tyr 650	-	expression tag
Ile 651	-	expression tag
Phe 652	-	expression tag
His 653	-	expression tag
Gly 654	-	expression tag
Ala 655	-	expression tag
Glu 656	-	expression tag
Val 657	-	expression tag
Tyr 658	-	expression tag
Ser 659	-	expression tag
Asp 660	-	expression tag
Ser 661	-	expression tag
Glu 662	-	expression tag
Asp 663	-	expression tag
Asp 664	-	expression tag
Val 665	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	40125.3
Non-Polymers*	Number of molecules	2
	Total formula weight	556.9
All*	Total formula weight	40682.1

*Water molecules are not included.