4ZYP
Crystal Structure of Motavizumab and Quaternary-Specific RSV-Neutralizing Human Antibody AM14 in Complex with Prefusion RSV F Glycoprotein
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Fusion glycoprotein F0,Fibritin | polymer | 498 | 55120.9 | 3 | UniProt (P03420) UniProt (D9IEJ2) Pfam (PF00523) | Human respiratory syncytial virus A (strain A2) | Protein F |
| 2 | D, L, N (J, K, N) | Motavizumab antibody Fab heavy chain | polymer | 225 | 24284.5 | 3 | Mus musculus (mouse) | ||
| 3 | E, M, O (L, M, O) | Motavizumab antibody light chain | polymer | 213 | 23150.7 | 3 | Mus musculus (mouse) | ||
| 4 | F, H, J (F, H, D) | AM14 antibody Fab heavy chain | polymer | 227 | 24365.2 | 3 | Homo sapiens (human) | ||
| 5 | G, I, K (G, I, E) | AM14 antibody light chain | polymer | 215 | 23615.2 | 3 | Homo sapiens (human) |
Sequence modifications
A, B, C: 26 - 513 (UniProt: P03420)
A, B, C: 518 - 544 (UniProt: D9IEJ2)
| PDB | External Database | Details |
|---|---|---|
| Ala 129 | Pro 102 | conflict |
| - | Arg 108 | deletion |
| - | Arg 109 | deletion |
| - | Glu 110 | deletion |
| - | Leu 111 | deletion |
| - | Pro 112 | deletion |
| - | Arg 113 | deletion |
| - | Phe 114 | deletion |
| - | Met 115 | deletion |
| - | Asn 116 | deletion |
| - | Tyr 117 | deletion |
| - | Thr 118 | deletion |
| - | Leu 119 | deletion |
| - | Asn 120 | deletion |
| - | Asn 121 | deletion |
| - | Ala 122 | deletion |
| - | Lys 123 | deletion |
| - | Lys 124 | deletion |
| - | Thr 125 | deletion |
| - | Asn 126 | deletion |
| - | Val 127 | deletion |
| - | Thr 128 | deletion |
| - | Leu 129 | deletion |
| - | Ser 130 | deletion |
| - | Lys 131 | deletion |
| - | Lys 132 | deletion |
| - | Arg 133 | deletion |
| - | Lys 134 | deletion |
| Cys 155 | Ser 155 | engineered mutation |
| Phe 190 | Ser 190 | engineered mutation |
| Leu 207 | Val 207 | engineered mutation |
| Cys 290 | Ser 290 | engineered mutation |
| Val 379 | Ile 379 | engineered mutation |
| Val 447 | Met 447 | engineered mutation |
| Ser 514 | - | linker |
| Ala 515 | - | linker |
| Ile 516 | - | linker |
| Gly 517 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 545 | - | expression tag |
| Gly 546 | - | expression tag |
| Leu 547 | - | expression tag |
| Val 548 | - | expression tag |
| Pro 549 | - | expression tag |
| Arg 550 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 15 |
| Total formula weight | 451609.4 | |
| All* | Total formula weight | 451609.4 |
