4ZWC

Crystal structure of maltose-bound human GLUT3 in the outward-open conformation at 2.6 angstrom

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Solute carrier family 2, facilitated glucose transporter member 3	polymer	518	56474.5	2	UniProt (P11169) Pfam (PF00083)	Homo sapiens (Human)	Glucose transporter type 3,brain,GLUT-3
2	C, D (C, D)	alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose	branched		342.3	2	In PDB BIRD (PRD_900001) GlyTouCan (G07411ON)		alpha-maltose
3	E, F, G (A, B)	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	non-polymer		356.5	3	Chemie (OLC)
4	H, I (A, B)	water	water		18.0	52	Chemie (HOH)

Sequence modifications

A, B: 1 - 496 (UniProt: P11169)

PDB	External Database	Details
Met -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Gly -9	-	expression tag
Asp -8	-	expression tag
Glu -7	-	expression tag
Val -6	-	expression tag
Asp -5	-	expression tag
Ala -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
His 0	-	expression tag
Thr 43	Asn 43	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	112949.0
Branched	Number of molecules	2
	Total formula weight	684.6
Non-Polymers*	Number of molecules	3
	Total formula weight	1069.6
All*	Total formula weight	114703.2

*Water molecules are not included.