4ZW9

Crystal structure of human GLUT3 bound to D-glucose in the outward-occluded conformation at 1.5 angstrom

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Solute carrier family 2, facilitated glucose transporter member 3	polymer	518	56474.5	1	UniProt (P11169) Pfam (PF00083)	Homo sapiens (Human)	Glucose transporter type 3,brain,GLUT-3
2	B, C, D (A)	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	non-polymer		356.5	3	Chemie (OLC)
3	E (A)	alpha-D-glucopyranose	non-polymer		180.2	1	Chemie (GLC)
4	F (A)	beta-D-glucopyranose	non-polymer		180.2	1	Chemie (BGC)
5	G (A)	water	water		18.0	101	Chemie (HOH)

Sequence modifications

A: 1 - 496 (UniProt: P11169)

PDB	External Database	Details
Met -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Gly -9	-	expression tag
Asp -8	-	expression tag
Glu -7	-	expression tag
Val -6	-	expression tag
Asp -5	-	expression tag
Ala -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
His 0	-	expression tag
Thr 43	Asn 43	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	56474.5
Non-Polymers*	Number of molecules	5
	Total formula weight	1429.9
All*	Total formula weight	57904.4

*Water molecules are not included.