4ZSO
Crystal structure of a complex between B7-H6, a tumor cell ligand for natural cytotoxicity receptor NKp30, and an inhibitory antibody
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Antibody Light Chain | polymer | 214 | 23508.1 | 2 | Homo sapiens | ||
2 | B, D | Antibody Heavy Chain | polymer | 219 | 23249.1 | 2 | Homo sapiens | ||
3 | E, F | Natural cytotoxicity triggering receptor 3 ligand 1 | polymer | 253 | 28319.9 | 2 | UniProt (Q68D85) Pfam (PF07654) In PDB | Homo sapiens (Human) | B7 homolog 6,B7-H6 |
4 | G | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
5 | H, J | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
6 | I | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
7 | B, D | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
8 | E, F | ACETIC ACID | non-polymer | 60.1 | 2 | Chemie (ACY) | |||
9 | water | water | 18.0 | 251 | Chemie (HOH) |
Sequence modifications
E, F: 25 - 262 (UniProt: Q68D85)
PDB | External Database | Details |
---|---|---|
Ala 19 | - | expression tag |
Asp 20 | - | expression tag |
Leu 21 | - | expression tag |
Gly 22 | - | expression tag |
Ser 23 | - | expression tag |
Met 24 | - | expression tag |
Ala 263 | - | expression tag |
Ala 264 | - | expression tag |
Ala 265 | - | expression tag |
His 266 | - | expression tag |
His 267 | - | expression tag |
His 268 | - | expression tag |
His 269 | - | expression tag |
His 270 | - | expression tag |
His 271 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 150154.2 | |
Branched | Number of molecules | 4 |
Total formula weight | 1786.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 312.2 | |
All* | Total formula weight | 152253.1 |