4ZSO

Crystal structure of a complex between B7-H6, a tumor cell ligand for natural cytotoxicity receptor NKp30, and an inhibitory antibody

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Antibody Light Chain	polymer	214	23508.1	2		Homo sapiens
2	B, D	Antibody Heavy Chain	polymer	219	23249.1	2		Homo sapiens
3	E, F	Natural cytotoxicity triggering receptor 3 ligand 1	polymer	253	28319.9	2	UniProt (Q68D85) Pfam (PF07654) In PDB	Homo sapiens (Human)	B7 homolog 6,B7-H6
4	G	alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		367.3	1	In PDB GlyTouCan (G86851RC)
5	H, J	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
6	I	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G21290RB)
7	B, D	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
8	E, F	ACETIC ACID	non-polymer		60.1	2	Chemie (ACY)
9		water	water		18.0	251	Chemie (HOH)

Sequence modifications

E, F: 25 - 262 (UniProt: Q68D85)

PDB	External Database	Details
Ala 19	-	expression tag
Asp 20	-	expression tag
Leu 21	-	expression tag
Gly 22	-	expression tag
Ser 23	-	expression tag
Met 24	-	expression tag
Ala 263	-	expression tag
Ala 264	-	expression tag
Ala 265	-	expression tag
His 266	-	expression tag
His 267	-	expression tag
His 268	-	expression tag
His 269	-	expression tag
His 270	-	expression tag
His 271	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	150154.2
Branched	Number of molecules	4
	Total formula weight	1786.7
Non-Polymers*	Number of molecules	4
	Total formula weight	312.2
All*	Total formula weight	152253.1

*Water molecules are not included.