4ZOG
VX-680/MK-0457 binds to human ABL1 also in inactive DFG conformations.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase ABL1 | polymer | 283 | 32767.4 | 2 | UniProt (P00519) Pfam (PF07714) | Homo sapiens (Human) | Abelson murine leukemia viral oncogene homolog 1,Abelson tyrosine-protein kinase 1,Proto-oncogene c-Abl,p150 |
| 2 | C, G (A, B) | CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE | non-polymer | 464.6 | 2 | Chemie (VX6) | |||
| 3 | D, E, F (A) | 2-METHOXYETHANOL | non-polymer | 76.1 | 3 | Chemie (MXE) | |||
| 4 | H (B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 125 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65534.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1352.7 | |
| All* | Total formula weight | 66887.5 |
