Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue VX6 A 601 |
| Chain | Residue |
| A | LEU248 |
| A | MET318 |
| A | THR319 |
| A | TYR320 |
| A | GLY321 |
| A | LEU370 |
| A | HOH751 |
| A | HOH767 |
| A | TYR253 |
| A | VAL256 |
| A | ALA269 |
| A | LYS271 |
| A | ILE313 |
| A | THR315 |
| A | GLU316 |
| A | PHE317 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue MXE A 602 |
| Chain | Residue |
| A | ASP363 |
| A | GLY383 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MXE A 603 |
| Chain | Residue |
| A | PHE401 |
| A | PRO402 |
| A | ILE403 |
| A | LYS404 |
| A | LEU445 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue VX6 B 601 |
| Chain | Residue |
| B | LEU248 |
| B | TYR253 |
| B | VAL256 |
| B | ALA269 |
| B | THR315 |
| B | GLU316 |
| B | PHE317 |
| B | MET318 |
| B | THR319 |
| B | GLY321 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue MES B 602 |
| Chain | Residue |
| A | GLU282 |
| A | ARG362 |
| A | TYR393 |
| A | HOH757 |
| A | HOH771 |
| B | VAL338 |
| B | TYR342 |
| B | ASN374 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGGGQYGEVYeGvwkkyslt..........VAVK |
| Chain | Residue | Details |
| A | LEU248-LYS271 | |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FIHrDLAARNCLV |
| Chain | Residue | Details |
| A | PHE359-VAL371 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ASP363 | |
| B | ASP363 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LEU248 | |
| A | LYS271 | |
| A | GLU316 | |
| B | LEU248 | |
| B | LYS271 | |
| B | GLU316 | |
| Chain | Residue | Details |
| A | SER229 | |
| B | SER229 | |
| Chain | Residue | Details |
| A | TYR253 | |
| A | TYR257 | |
| A | TYR413 | |
| B | TYR253 | |
| B | TYR257 | |
| B | TYR413 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases => ECO:0000269|PubMed:16912036 |
| Chain | Residue | Details |
| A | TYR393 | |
| B | TYR393 | |
| Chain | Residue | Details |
| A | SER446 | |
| B | SER446 | |
