4ZNC

Fc fragment of human IgG in complex with the C domain of staphylococcal protein A mutant - Q9W

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Immunoglobulin G-binding protein A	polymer	58	6695.4	3	UniProt (P38507) Pfam (PF02216)	Staphylococcus aureus	IgG-binding protein A,Staphylococcal protein A
2	D, E, F (D, E, F)	Ig gamma-3 chain C region	polymer	220	25124.4	3	UniProt (P01860) Pfam (PF07654)	Homo sapiens (Human)	HDC,Heavy chain disease protein
3	G, H, I, J, K... (A, B, C, D, E...)	water	water		18.0	126	Chemie (HOH)

Sequence modifications

A, B, C: 1 - 58 (UniProt: P38507)

PDB	External Database	Details
Trp 9	Gln 278	engineered mutation

D, E, F: 238 - 447 (UniProt: P01860)

PDB	External Database	Details
Phe 296	Tyr 226	conflict
His 435	Arg 365	conflict
Tyr 436	Phe 366	conflict
Gly 448	-	expression tag
Ser 449	-	expression tag
Leu 450	-	expression tag
Glu 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag
His 455	-	expression tag
His 456	-	expression tag
His 457	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	95459.4
All*	Total formula weight	95459.4

*Water molecules are not included.