4ZLZ
Crystal Structure of Bruton's Tyrosine Kinase in complex with a substituted Cinnoline
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase BTK | polymer | 270 | 31511.2 | 1 | UniProt (Q06187) Pfam (PF07714) | Homo sapiens (Human) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase |
| 2 | B, D (A) | IMIDAZOLE | non-polymer | 69.1 | 2 | Chemie (IMD) | |||
| 3 | C (A) | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 1 | Chemie (IPA) | |||
| 4 | E (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | F (A) | 4-amino-8-(4-methylpyridin-3-yl)cinnoline-3-carboxamide | non-polymer | 279.3 | 1 | Chemie (4RV) | |||
| 6 | G (A) | water | water | 18.0 | 338 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31511.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 555.7 | |
| All* | Total formula weight | 32066.9 |
