4ZH1

Complement factor H in complex with the GM1 glycan

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Complement C3	polymer	317	35444.4	3	UniProt (P01024) Pfam (PF07678) In PDB	Homo sapiens (Human)	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
2	D, E, F	Complement factor H	polymer	129	14773.8	3	UniProt (P08603) Pfam (PF00084) In PDB	Homo sapiens (Human)	H factor 1
3	G	N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose	branched		471.4	1	In PDB GlyTouCan (G30207PZ)
4	H	beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose	branched		998.9	1	In PDB GlyTouCan (G48558GR)
5	I	N-acetyl-alpha-neuraminic acid-(2-3)-[2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose	branched		836.7	1	In PDB GlyTouCan (G79389NT)
6	A, B, C, D	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
7		water	water		18.0	448	Chemie (HOH)

Sequence modifications

A, B, C: 3 - 310 (UniProt: P01024)

PDB	External Database	Details
Gly -6	-	expression tag
Pro -5	-	expression tag
Leu -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Pro -1	-	expression tag
Glu 0	-	expression tag
Phe 1	-	expression tag
Arg 2	-	expression tag
Ala 17	Cys 1010	conflict

D, E, F: 1107 - 1231 (UniProt: P08603)

PDB	External Database	Details
Glu 1103	-	expression tag
Ala 1104	-	expression tag
Glu 1105	-	expression tag
Phe 1106	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	150654.7
Branched	Number of molecules	3
	Total formula weight	2307.0
Non-Polymers*	Number of molecules	4
	Total formula weight	368.4
All*	Total formula weight	153330.1

*Water molecules are not included.