4ZH1
Complement factor H in complex with the GM1 glycan
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Complement C3 | polymer | 317 | 35444.4 | 3 | UniProt (P01024) Pfam (PF07678) | Homo sapiens (Human) | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 |
| 2 | D, E, F (D, E, F) | Complement factor H | polymer | 129 | 14773.8 | 3 | UniProt (P08603) Pfam (PF00084) | Homo sapiens (Human) | H factor 1 |
| 3 | G (G) | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose | branched | 471.4 | 1 | In PDB GlyTouCan (G30207PZ) | |||
| 4 | H (H) | beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | branched | 998.9 | 1 | In PDB GlyTouCan (G48558GR) | |||
| 5 | I (I) | N-acetyl-alpha-neuraminic acid-(2-3)-[2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | branched | 836.7 | 1 | In PDB GlyTouCan (G79389NT) | |||
| 6 | J, K, L, M (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 7 | N, O, P, Q, R... (A, B, C, D, E...) | water | water | 18.0 | 448 | Chemie (HOH) |
Sequence modifications
A, B, C: 3 - 310 (UniProt: P01024)
D, E, F: 1107 - 1231 (UniProt: P08603)
| PDB | External Database | Details |
|---|---|---|
| Gly -6 | - | expression tag |
| Pro -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Glu 0 | - | expression tag |
| Phe 1 | - | expression tag |
| Arg 2 | - | expression tag |
| Ala 17 | Cys 1010 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Glu 1103 | - | expression tag |
| Ala 1104 | - | expression tag |
| Glu 1105 | - | expression tag |
| Phe 1106 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 150654.7 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 2307.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 368.4 | |
| All* | Total formula weight | 153330.1 |
