4ZGX
Structure of aldosterone synthase (CYP11B2) in complex with (+)-(R)-N-(4-(4-chloro-3-fluorophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Cytochrome P450 11B2, mitochondrial | polymer | 489 | 56242.2 | 12 | UniProt (P19099) Pfam (PF00067) In PDB | Homo sapiens (Human) | Aldosterone synthase,ALDOS,Aldosterone-synthesizing enzyme,CYPXIB2,Cytochrome P-450Aldo,Cytochrome P-450C18,Steroid 18-hydroxylase |
2 | I, J, K, L, A... | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 12 | Chemie (HEM) | |||
3 | I, J, K, L, A... | N-[(8R)-4-(4-chloro-3-fluorophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl]propanamide | non-polymer | 332.8 | 10 | Chemie (QHC) | |||
4 | water | water | 18.0 | 817 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 28 - 503 (UniProt: P19099)
PDB | External Database | Details |
---|---|---|
Met 24 | - | expression tag |
Ala 25 | - | expression tag |
Thr 26 | - | expression tag |
Lys 27 | - | expression tag |
Gly 504 | - | expression tag |
Gly 505 | - | expression tag |
Arg 506 | - | expression tag |
His 507 | - | expression tag |
His 508 | - | expression tag |
His 509 | - | expression tag |
His 510 | - | expression tag |
His 511 | - | expression tag |
His 512 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 674906.4 | |
Non-Polymers* | Number of molecules | 22 |
Total formula weight | 10725.8 | |
All* | Total formula weight | 685632.2 |