4ZGX

Structure of aldosterone synthase (CYP11B2) in complex with (+)-(R)-N-(4-(4-chloro-3-fluorophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002017	biological_process	regulation of blood volume by renal aldosterone
A	0003091	biological_process	renal water homeostasis
A	0004497	molecular_function	monooxygenase activity
A	0004507	molecular_function	steroid 11-beta-monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006629	biological_process	lipid metabolic process
A	0006694	biological_process	steroid biosynthetic process
A	0006700	biological_process	C21-steroid hormone biosynthetic process
A	0006704	biological_process	glucocorticoid biosynthetic process
A	0006705	biological_process	mineralocorticoid biosynthetic process
A	0008203	biological_process	cholesterol metabolic process
A	0008395	molecular_function	steroid hydroxylase activity
A	0016125	biological_process	sterol metabolic process
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0020037	molecular_function	heme binding
A	0032342	biological_process	aldosterone biosynthetic process
A	0032870	biological_process	cellular response to hormone stimulus
A	0034650	biological_process	cortisol metabolic process
A	0034651	biological_process	cortisol biosynthetic process
A	0035865	biological_process	cellular response to potassium ion
A	0046872	molecular_function	metal ion binding
A	0047783	molecular_function	corticosterone 18-monooxygenase activity
A	0055075	biological_process	potassium ion homeostasis
A	0055078	biological_process	sodium ion homeostasis
A	0071375	biological_process	cellular response to peptide hormone stimulus
A	1901615	biological_process	organic hydroxy compound metabolic process
B	0002017	biological_process	regulation of blood volume by renal aldosterone
B	0003091	biological_process	renal water homeostasis
B	0004497	molecular_function	monooxygenase activity
B	0004507	molecular_function	steroid 11-beta-monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006629	biological_process	lipid metabolic process
B	0006694	biological_process	steroid biosynthetic process
B	0006700	biological_process	C21-steroid hormone biosynthetic process
B	0006704	biological_process	glucocorticoid biosynthetic process
B	0006705	biological_process	mineralocorticoid biosynthetic process
B	0008203	biological_process	cholesterol metabolic process
B	0008395	molecular_function	steroid hydroxylase activity
B	0016125	biological_process	sterol metabolic process
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0020037	molecular_function	heme binding
B	0032342	biological_process	aldosterone biosynthetic process
B	0032870	biological_process	cellular response to hormone stimulus
B	0034650	biological_process	cortisol metabolic process
B	0034651	biological_process	cortisol biosynthetic process
B	0035865	biological_process	cellular response to potassium ion
B	0046872	molecular_function	metal ion binding
B	0047783	molecular_function	corticosterone 18-monooxygenase activity
B	0055075	biological_process	potassium ion homeostasis
B	0055078	biological_process	sodium ion homeostasis
B	0071375	biological_process	cellular response to peptide hormone stimulus
B	1901615	biological_process	organic hydroxy compound metabolic process
C	0002017	biological_process	regulation of blood volume by renal aldosterone
C	0003091	biological_process	renal water homeostasis
C	0004497	molecular_function	monooxygenase activity
C	0004507	molecular_function	steroid 11-beta-monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006629	biological_process	lipid metabolic process
C	0006694	biological_process	steroid biosynthetic process
C	0006700	biological_process	C21-steroid hormone biosynthetic process
C	0006704	biological_process	glucocorticoid biosynthetic process
C	0006705	biological_process	mineralocorticoid biosynthetic process
C	0008203	biological_process	cholesterol metabolic process
C	0008395	molecular_function	steroid hydroxylase activity
C	0016125	biological_process	sterol metabolic process
C	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C	0020037	molecular_function	heme binding
C	0032342	biological_process	aldosterone biosynthetic process
C	0032870	biological_process	cellular response to hormone stimulus
C	0034650	biological_process	cortisol metabolic process
C	0034651	biological_process	cortisol biosynthetic process
C	0035865	biological_process	cellular response to potassium ion
C	0046872	molecular_function	metal ion binding
C	0047783	molecular_function	corticosterone 18-monooxygenase activity
C	0055075	biological_process	potassium ion homeostasis
C	0055078	biological_process	sodium ion homeostasis
C	0071375	biological_process	cellular response to peptide hormone stimulus
C	1901615	biological_process	organic hydroxy compound metabolic process
D	0002017	biological_process	regulation of blood volume by renal aldosterone
D	0003091	biological_process	renal water homeostasis
D	0004497	molecular_function	monooxygenase activity
D	0004507	molecular_function	steroid 11-beta-monooxygenase activity
D	0005506	molecular_function	iron ion binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0006629	biological_process	lipid metabolic process
D	0006694	biological_process	steroid biosynthetic process
D	0006700	biological_process	C21-steroid hormone biosynthetic process
D	0006704	biological_process	glucocorticoid biosynthetic process
D	0006705	biological_process	mineralocorticoid biosynthetic process
D	0008203	biological_process	cholesterol metabolic process
D	0008395	molecular_function	steroid hydroxylase activity
D	0016125	biological_process	sterol metabolic process
D	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
D	0020037	molecular_function	heme binding
D	0032342	biological_process	aldosterone biosynthetic process
D	0032870	biological_process	cellular response to hormone stimulus
D	0034650	biological_process	cortisol metabolic process
D	0034651	biological_process	cortisol biosynthetic process
D	0035865	biological_process	cellular response to potassium ion
D	0046872	molecular_function	metal ion binding
D	0047783	molecular_function	corticosterone 18-monooxygenase activity
D	0055075	biological_process	potassium ion homeostasis
D	0055078	biological_process	sodium ion homeostasis
D	0071375	biological_process	cellular response to peptide hormone stimulus
D	1901615	biological_process	organic hydroxy compound metabolic process
E	0002017	biological_process	regulation of blood volume by renal aldosterone
E	0003091	biological_process	renal water homeostasis
E	0004497	molecular_function	monooxygenase activity
E	0004507	molecular_function	steroid 11-beta-monooxygenase activity
E	0005506	molecular_function	iron ion binding
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0006629	biological_process	lipid metabolic process
E	0006694	biological_process	steroid biosynthetic process
E	0006700	biological_process	C21-steroid hormone biosynthetic process
E	0006704	biological_process	glucocorticoid biosynthetic process
E	0006705	biological_process	mineralocorticoid biosynthetic process
E	0008203	biological_process	cholesterol metabolic process
E	0008395	molecular_function	steroid hydroxylase activity
E	0016125	biological_process	sterol metabolic process
E	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
E	0020037	molecular_function	heme binding
E	0032342	biological_process	aldosterone biosynthetic process
E	0032870	biological_process	cellular response to hormone stimulus
E	0034650	biological_process	cortisol metabolic process
E	0034651	biological_process	cortisol biosynthetic process
E	0035865	biological_process	cellular response to potassium ion
E	0046872	molecular_function	metal ion binding
E	0047783	molecular_function	corticosterone 18-monooxygenase activity
E	0055075	biological_process	potassium ion homeostasis
E	0055078	biological_process	sodium ion homeostasis
E	0071375	biological_process	cellular response to peptide hormone stimulus
E	1901615	biological_process	organic hydroxy compound metabolic process
F	0002017	biological_process	regulation of blood volume by renal aldosterone
F	0003091	biological_process	renal water homeostasis
F	0004497	molecular_function	monooxygenase activity
F	0004507	molecular_function	steroid 11-beta-monooxygenase activity
F	0005506	molecular_function	iron ion binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0006629	biological_process	lipid metabolic process
F	0006694	biological_process	steroid biosynthetic process
F	0006700	biological_process	C21-steroid hormone biosynthetic process
F	0006704	biological_process	glucocorticoid biosynthetic process
F	0006705	biological_process	mineralocorticoid biosynthetic process
F	0008203	biological_process	cholesterol metabolic process
F	0008395	molecular_function	steroid hydroxylase activity
F	0016125	biological_process	sterol metabolic process
F	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
F	0020037	molecular_function	heme binding
F	0032342	biological_process	aldosterone biosynthetic process
F	0032870	biological_process	cellular response to hormone stimulus
F	0034650	biological_process	cortisol metabolic process
F	0034651	biological_process	cortisol biosynthetic process
F	0035865	biological_process	cellular response to potassium ion
F	0046872	molecular_function	metal ion binding
F	0047783	molecular_function	corticosterone 18-monooxygenase activity
F	0055075	biological_process	potassium ion homeostasis
F	0055078	biological_process	sodium ion homeostasis
F	0071375	biological_process	cellular response to peptide hormone stimulus
F	1901615	biological_process	organic hydroxy compound metabolic process
G	0002017	biological_process	regulation of blood volume by renal aldosterone
G	0003091	biological_process	renal water homeostasis
G	0004497	molecular_function	monooxygenase activity
G	0004507	molecular_function	steroid 11-beta-monooxygenase activity
G	0005506	molecular_function	iron ion binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0006629	biological_process	lipid metabolic process
G	0006694	biological_process	steroid biosynthetic process
G	0006700	biological_process	C21-steroid hormone biosynthetic process
G	0006704	biological_process	glucocorticoid biosynthetic process
G	0006705	biological_process	mineralocorticoid biosynthetic process
G	0008203	biological_process	cholesterol metabolic process
G	0008395	molecular_function	steroid hydroxylase activity
G	0016125	biological_process	sterol metabolic process
G	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
G	0020037	molecular_function	heme binding
G	0032342	biological_process	aldosterone biosynthetic process
G	0032870	biological_process	cellular response to hormone stimulus
G	0034650	biological_process	cortisol metabolic process
G	0034651	biological_process	cortisol biosynthetic process
G	0035865	biological_process	cellular response to potassium ion
G	0046872	molecular_function	metal ion binding
G	0047783	molecular_function	corticosterone 18-monooxygenase activity
G	0055075	biological_process	potassium ion homeostasis
G	0055078	biological_process	sodium ion homeostasis
G	0071375	biological_process	cellular response to peptide hormone stimulus
G	1901615	biological_process	organic hydroxy compound metabolic process
H	0002017	biological_process	regulation of blood volume by renal aldosterone
H	0003091	biological_process	renal water homeostasis
H	0004497	molecular_function	monooxygenase activity
H	0004507	molecular_function	steroid 11-beta-monooxygenase activity
H	0005506	molecular_function	iron ion binding
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006629	biological_process	lipid metabolic process
H	0006694	biological_process	steroid biosynthetic process
H	0006700	biological_process	C21-steroid hormone biosynthetic process
H	0006704	biological_process	glucocorticoid biosynthetic process
H	0006705	biological_process	mineralocorticoid biosynthetic process
H	0008203	biological_process	cholesterol metabolic process
H	0008395	molecular_function	steroid hydroxylase activity
H	0016125	biological_process	sterol metabolic process
H	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
H	0020037	molecular_function	heme binding
H	0032342	biological_process	aldosterone biosynthetic process
H	0032870	biological_process	cellular response to hormone stimulus
H	0034650	biological_process	cortisol metabolic process
H	0034651	biological_process	cortisol biosynthetic process
H	0035865	biological_process	cellular response to potassium ion
H	0046872	molecular_function	metal ion binding
H	0047783	molecular_function	corticosterone 18-monooxygenase activity
H	0055075	biological_process	potassium ion homeostasis
H	0055078	biological_process	sodium ion homeostasis
H	0071375	biological_process	cellular response to peptide hormone stimulus
H	1901615	biological_process	organic hydroxy compound metabolic process
I	0002017	biological_process	regulation of blood volume by renal aldosterone
I	0003091	biological_process	renal water homeostasis
I	0004497	molecular_function	monooxygenase activity
I	0004507	molecular_function	steroid 11-beta-monooxygenase activity
I	0005506	molecular_function	iron ion binding
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0006629	biological_process	lipid metabolic process
I	0006694	biological_process	steroid biosynthetic process
I	0006700	biological_process	C21-steroid hormone biosynthetic process
I	0006704	biological_process	glucocorticoid biosynthetic process
I	0006705	biological_process	mineralocorticoid biosynthetic process
I	0008203	biological_process	cholesterol metabolic process
I	0008395	molecular_function	steroid hydroxylase activity
I	0016125	biological_process	sterol metabolic process
I	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
I	0020037	molecular_function	heme binding
I	0032342	biological_process	aldosterone biosynthetic process
I	0032870	biological_process	cellular response to hormone stimulus
I	0034650	biological_process	cortisol metabolic process
I	0034651	biological_process	cortisol biosynthetic process
I	0035865	biological_process	cellular response to potassium ion
I	0046872	molecular_function	metal ion binding
I	0047783	molecular_function	corticosterone 18-monooxygenase activity
I	0055075	biological_process	potassium ion homeostasis
I	0055078	biological_process	sodium ion homeostasis
I	0071375	biological_process	cellular response to peptide hormone stimulus
I	1901615	biological_process	organic hydroxy compound metabolic process
J	0002017	biological_process	regulation of blood volume by renal aldosterone
J	0003091	biological_process	renal water homeostasis
J	0004497	molecular_function	monooxygenase activity
J	0004507	molecular_function	steroid 11-beta-monooxygenase activity
J	0005506	molecular_function	iron ion binding
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006629	biological_process	lipid metabolic process
J	0006694	biological_process	steroid biosynthetic process
J	0006700	biological_process	C21-steroid hormone biosynthetic process
J	0006704	biological_process	glucocorticoid biosynthetic process
J	0006705	biological_process	mineralocorticoid biosynthetic process
J	0008203	biological_process	cholesterol metabolic process
J	0008395	molecular_function	steroid hydroxylase activity
J	0016125	biological_process	sterol metabolic process
J	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
J	0020037	molecular_function	heme binding
J	0032342	biological_process	aldosterone biosynthetic process
J	0032870	biological_process	cellular response to hormone stimulus
J	0034650	biological_process	cortisol metabolic process
J	0034651	biological_process	cortisol biosynthetic process
J	0035865	biological_process	cellular response to potassium ion
J	0046872	molecular_function	metal ion binding
J	0047783	molecular_function	corticosterone 18-monooxygenase activity
J	0055075	biological_process	potassium ion homeostasis
J	0055078	biological_process	sodium ion homeostasis
J	0071375	biological_process	cellular response to peptide hormone stimulus
J	1901615	biological_process	organic hydroxy compound metabolic process
K	0002017	biological_process	regulation of blood volume by renal aldosterone
K	0003091	biological_process	renal water homeostasis
K	0004497	molecular_function	monooxygenase activity
K	0004507	molecular_function	steroid 11-beta-monooxygenase activity
K	0005506	molecular_function	iron ion binding
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0006629	biological_process	lipid metabolic process
K	0006694	biological_process	steroid biosynthetic process
K	0006700	biological_process	C21-steroid hormone biosynthetic process
K	0006704	biological_process	glucocorticoid biosynthetic process
K	0006705	biological_process	mineralocorticoid biosynthetic process
K	0008203	biological_process	cholesterol metabolic process
K	0008395	molecular_function	steroid hydroxylase activity
K	0016125	biological_process	sterol metabolic process
K	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
K	0020037	molecular_function	heme binding
K	0032342	biological_process	aldosterone biosynthetic process
K	0032870	biological_process	cellular response to hormone stimulus
K	0034650	biological_process	cortisol metabolic process
K	0034651	biological_process	cortisol biosynthetic process
K	0035865	biological_process	cellular response to potassium ion
K	0046872	molecular_function	metal ion binding
K	0047783	molecular_function	corticosterone 18-monooxygenase activity
K	0055075	biological_process	potassium ion homeostasis
K	0055078	biological_process	sodium ion homeostasis
K	0071375	biological_process	cellular response to peptide hormone stimulus
K	1901615	biological_process	organic hydroxy compound metabolic process
L	0002017	biological_process	regulation of blood volume by renal aldosterone
L	0003091	biological_process	renal water homeostasis
L	0004497	molecular_function	monooxygenase activity
L	0004507	molecular_function	steroid 11-beta-monooxygenase activity
L	0005506	molecular_function	iron ion binding
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0006629	biological_process	lipid metabolic process
L	0006694	biological_process	steroid biosynthetic process
L	0006700	biological_process	C21-steroid hormone biosynthetic process
L	0006704	biological_process	glucocorticoid biosynthetic process
L	0006705	biological_process	mineralocorticoid biosynthetic process
L	0008203	biological_process	cholesterol metabolic process
L	0008395	molecular_function	steroid hydroxylase activity
L	0016125	biological_process	sterol metabolic process
L	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
L	0020037	molecular_function	heme binding
L	0032342	biological_process	aldosterone biosynthetic process
L	0032870	biological_process	cellular response to hormone stimulus
L	0034650	biological_process	cortisol metabolic process
L	0034651	biological_process	cortisol biosynthetic process
L	0035865	biological_process	cellular response to potassium ion
L	0046872	molecular_function	metal ion binding
L	0047783	molecular_function	corticosterone 18-monooxygenase activity
L	0055075	biological_process	potassium ion homeostasis
L	0055078	biological_process	sodium ion homeostasis
L	0071375	biological_process	cellular response to peptide hormone stimulus
L	1901615	biological_process	organic hydroxy compound metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue HEM A 601

Chain	Residue
A	ARG110
A	VAL378
A	LEU382
A	ARG384
A	PRO442
A	PHE443
A	GLY444
A	PHE445
A	ARG448
A	GLN449
A	CYS450
A	VAL129
A	ALA456
A	MET460
A	QHC602
A	PHE130
A	TRP137
A	ARG141
A	LEU311
A	SER315
A	THR318
A	THR319

---

site_id	AC2
Number of Residues	10
Details	binding site for residue QHC A 602

Chain	Residue
A	TRP116
A	PHE130
A	TRP260
A	GLU310
A	GLY314
A	VAL378
A	GLY379
A	PHE381
A	ILE488
A	HEM601

---

site_id	AC3
Number of Residues	22
Details	binding site for residue HEM B 601

Chain	Residue
B	ARG110
B	VAL129
B	PHE130
B	TRP137
B	ARG141
B	GLY314
B	SER315
B	THR318
B	THR319
B	VAL378
B	LEU382
B	ARG384
B	PRO442
B	PHE443
B	GLY444
B	PHE445
B	ARG448
B	CYS450
B	GLY452
B	LEU455
B	ALA456
B	QHC602

---

site_id	AC4
Number of Residues	10
Details	binding site for residue QHC B 602

Chain	Residue
B	TRP116
B	PHE130
B	GLU310
B	ALA313
B	GLY314
B	GLY379
B	LEU407
B	PRO442
B	ILE488
B	HEM601

---

site_id	AC5
Number of Residues	22
Details	binding site for residue HEM C 601

Chain	Residue
C	ARG110
C	VAL129
C	PHE130
C	TRP137
C	ARG141
C	GLY314
C	SER315
C	THR318
C	THR319
C	LEU382
C	ARG384
C	PRO442
C	PHE443
C	GLY444
C	PHE445
C	ARG448
C	CYS450
C	GLY452
C	LEU455
C	ALA456
C	MET460
C	QHC602

---

site_id	AC6
Number of Residues	11
Details	binding site for residue QHC C 602

Chain	Residue
C	TRP116
C	PHE130
C	GLU310
C	GLY314
C	GLY379
C	LEU380
C	PHE381
C	LEU407
C	PHE487
C	ILE488
C	HEM601

---

site_id	AC7
Number of Residues	22
Details	binding site for residue HEM D 601

Chain	Residue
D	PHE130
D	TRP137
D	ARG141
D	LEU311
D	GLY314
D	SER315
D	THR318
D	THR319
D	LEU373
D	VAL378
D	LEU382
D	ARG384
D	PRO442
D	PHE443
D	PHE445
D	ARG448
D	GLN449
D	CYS450
D	LEU455
D	QHC602
D	ARG110
D	VAL129

---

site_id	AC8
Number of Residues	9
Details	binding site for residue QHC D 602

Chain	Residue
D	TRP116
D	PHE130
D	GLU310
D	GLY314
D	THR318
D	GLY379
D	PHE381
D	ILE488
D	HEM601

---

site_id	AC9
Number of Residues	22
Details	binding site for residue HEM E 601

Chain	Residue
E	ARG110
E	VAL129
E	PHE130
E	TRP137
E	ARG141
E	GLY314
E	SER315
E	THR318
E	THR319
E	LEU373
E	VAL378
E	LEU382
E	ARG384
E	PRO442
E	PHE443
E	PHE445
E	ARG448
E	CYS450
E	GLY452
E	LEU455
E	ALA456
E	QHC602

---

site_id	AD1
Number of Residues	9
Details	binding site for residue QHC E 602

Chain	Residue
E	TRP116
E	PHE130
E	GLU310
E	GLY314
E	VAL378
E	GLY379
E	PHE381
E	PHE487
E	HEM601

---

site_id	AD2
Number of Residues	20
Details	binding site for residue HEM F 601

Chain	Residue
F	ARG110
F	VAL129
F	PHE130
F	TRP137
F	ARG141
F	LEU311
F	GLY314
F	THR318
F	THR319
F	VAL378
F	LEU382
F	ARG384
F	PRO442
F	PHE443
F	PHE445
F	ARG448
F	CYS450
F	GLY452
F	ALA456
F	QHC602

---

site_id	AD3
Number of Residues	11
Details	binding site for residue QHC F 602

Chain	Residue
F	TRP116
F	PHE130
F	GLU310
F	GLY314
F	GLY379
F	PHE381
F	LEU407
F	PHE487
F	ILE488
F	HEM601
F	HOH720

---

site_id	AD4
Number of Residues	21
Details	binding site for residue HEM G 601

Chain	Residue
G	ARG110
G	VAL129
G	PHE130
G	TRP137
G	ARG141
G	LEU311
G	GLY314
G	SER315
G	THR318
G	THR319
G	VAL378
G	LEU382
G	ARG384
G	PRO442
G	PHE443
G	GLY444
G	PHE445
G	ARG448
G	CYS450
G	GLY452
G	ALA456

---

site_id	AD5
Number of Residues	23
Details	binding site for residue HEM H 601

Chain	Residue
H	ARG110
H	VAL129
H	PHE130
H	TRP137
H	ARG141
H	LEU311
H	GLY314
H	THR318
H	THR319
H	LEU373
H	VAL378
H	LEU382
H	ARG384
H	PRO442
H	PHE443
H	GLY444
H	PHE445
H	ARG448
H	GLN449
H	CYS450
H	LEU451
H	GLY452
H	ALA456

---

site_id	AD6
Number of Residues	22
Details	binding site for residue HEM I 601

Chain	Residue
I	ARG110
I	VAL129
I	PHE130
I	TRP137
I	ARG141
I	GLY314
I	THR318
I	THR319
I	VAL378
I	LEU382
I	ARG384
I	PRO442
I	PHE443
I	GLY444
I	PHE445
I	ARG448
I	GLN449
I	CYS450
I	GLY452
I	LEU455
I	ALA456
I	QHC602

---

site_id	AD7
Number of Residues	9
Details	binding site for residue QHC I 602

Chain	Residue
I	TRP116
I	PHE130
I	GLU310
I	ALA313
I	GLY314
I	GLY379
I	PHE381
I	LEU407
I	HEM601

---

site_id	AD8
Number of Residues	21
Details	binding site for residue HEM J 601

Chain	Residue
J	ARG110
J	VAL129
J	TRP137
J	ARG141
J	LEU311
J	GLY314
J	THR318
J	THR319
J	LEU373
J	VAL378
J	ARG384
J	PRO442
J	PHE443
J	GLY444
J	PHE445
J	ARG448
J	CYS450
J	GLY452
J	LEU455
J	ALA456
J	QHC602

---

site_id	AD9
Number of Residues	9
Details	binding site for residue QHC J 602

Chain	Residue
J	TRP116
J	PHE130
J	ALA313
J	GLY314
J	VAL378
J	GLY379
J	PHE381
J	PHE487
J	HEM601

---

site_id	AE1
Number of Residues	22
Details	binding site for residue HEM K 601

Chain	Residue
K	ARG110
K	VAL129
K	PHE130
K	TRP137
K	ARG141
K	LEU311
K	GLY314
K	SER315
K	THR318
K	THR319
K	LEU373
K	VAL378
K	LEU382
K	ARG384
K	PRO442
K	PHE443
K	GLY444
K	ARG448
K	CYS450
K	GLY452
K	MET460
K	QHC602

---

site_id	AE2
Number of Residues	9
Details	binding site for residue QHC K 602

Chain	Residue
K	TRP116
K	PHE130
K	GLU310
K	GLY314
K	GLY379
K	PHE381
K	LEU407
K	PHE487
K	HEM601

---

site_id	AE3
Number of Residues	21
Details	binding site for residue HEM L 601

Chain	Residue
L	ARG110
L	VAL129
L	PHE130
L	TRP137
L	ARG141
L	LEU311
L	GLY314
L	SER315
L	THR318
L	THR319
L	LEU382
L	GLU383
L	ARG384
L	PRO442
L	PHE443
L	GLY444
L	ARG448
L	CYS450
L	GLY452
L	MET460
L	QHC602

---

site_id	AE4
Number of Residues	12
Details	binding site for residue QHC L 602

Chain	Residue
L	TRP116
L	PHE130
L	GLU310
L	GLY314
L	THR318
L	VAL378
L	GLY379
L	PHE381
L	LEU407
L	PHE487
L	ILE488
L	HEM601

---

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGfGMRQCLG

Chain	Residue	Details
A	PHE443-GLY452

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:23322723, ECO:0007744|PDB:4DVQ

Chain	Residue	Details
A	PHE381
J	PHE381
K	PHE381
L	PHE381
B	PHE381
C	PHE381
D	PHE381
E	PHE381
F	PHE381
G	PHE381
H	PHE381
I	PHE381

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: axial binding residue => ECO:0000269|PubMed:23322723, ECO:0007744|PDB:4DVQ, ECO:0007744|PDB:4FDH

Chain	Residue	Details
A	CYS450
J	CYS450
K	CYS450
L	CYS450
B	CYS450
C	CYS450
D	CYS450
E	CYS450
F	CYS450
G	CYS450
H	CYS450
I	CYS450

---