4ZGM

Crystal structure of Semaglutide peptide backbone in complex with the GLP-1 receptor extracellular domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Glucagon-like peptide 1 receptor	polymer	122	14325.8	1	UniProt (P43220) Pfam (PF02793) In PDB	Homo sapiens (Human)	GLP-1R
2	B	Semaglutide peptide backbone; 8Aib,34R-GLP-1(7-37)-OH	polymer	31	3401.7	1	Pfam (PF00123) UniProt (by SIFTS) (P01275) In PDB	Homo sapiens
3	A, B	3,6,9,12,15,18-hexaoxahexacosan-1-ol	non-polymer		394.5	2	Chemie (32M)
4		water	water		18.0	88	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	17727.6
Non-Polymers*	Number of molecules	2
	Total formula weight	789.1
All*	Total formula weight	18516.7

*Water molecules are not included.