4ZGM

Crystal structure of Semaglutide peptide backbone in complex with the GLP-1 receptor extracellular domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004967	molecular_function	glucagon receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0008528	molecular_function	G protein-coupled peptide receptor activity
A	0016020	cellular_component	membrane
B	0005179	molecular_function	hormone activity
B	0005576	cellular_component	extracellular region

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue 32M A 201

Chain	Residue
A	HOH302

---

site_id	AC2
Number of Residues	3
Details	binding site for residue 32M B 101

Chain	Residue
B	LEU20
B	ALA24
B	ARG36

---

Functional Information from PROSITE/UniProt

site_id	PS00260
Number of Residues	23
Details	GLUCAGON Glucagon / GIP / secretin / VIP family signature. HAEGTFtSDVssylegqaAKEFI

Chain	Residue	Details
B	HIS7-ILE29

---

site_id	PS00649
Number of Residues	25
Details	G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtFDeya.CWpdGepgsfvnvsCP

Chain	Residue	Details
A	CYS62-PRO86

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P55095

Chain	Residue	Details
B	SER14
B	SER17

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Arginine amide => ECO:0000269|PubMed:2753890

Chain	Residue	Details
B	ARG36
A	GLU128

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22412906

Chain	Residue	Details
A	ASN63
A	ASN82
A	ASN115

---