4ZGM

Crystal structure of Semaglutide peptide backbone in complex with the GLP-1 receptor extracellular domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004967	molecular_function	glucagon receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0008528	molecular_function	G protein-coupled peptide receptor activity
A	0016020	cellular_component	membrane
B	0005179	molecular_function	hormone activity
B	0005576	cellular_component	extracellular region

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue 32M A 201

Chain	Residue
A	HOH302

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site_id	AC2
Number of Residues	3
Details	binding site for residue 32M B 101

Chain	Residue
B	LEU20
B	ALA24
B	ARG36

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Functional Information from PROSITE/UniProt

site_id	PS00260
Number of Residues	23
Details	GLUCAGON Glucagon / GIP / secretin / VIP family signature. HAEGTFtSDVssylegqaAKEFI

Chain	Residue	Details
B	HIS7-ILE29

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site_id	PS00649
Number of Residues	25
Details	G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtFDeya.CWpdGepgsfvnvsCP

Chain	Residue	Details
A	CYS62-PRO86

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Site: {"description":"Interaction with the endogenous ligand GLP-1","evidences":[{"source":"PubMed","id":"19861722","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22412906","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P55095","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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