4ZFG

Dual-specificity Fab 5A12 in complex with Angiopoietin 2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Angiopoietin-2	polymer	232	26530.4	1	UniProt (O15123) Pfam (PF00147) In PDB	Homo sapiens (Human)	ANG-2
2	H	Fragment antigen binding 5A12 heavy chain	polymer	228	24231.2	1		Homo sapiens
3	L	Fragment antigen binding 5A12 light chain	polymer	215	23296.9	1		Homo sapiens
4	A	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
5	A, H	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
6		water	water		18.0	397	Chemie (HOH)

Sequence modifications

A: 277 - 496 (UniProt: O15123)

PDB	External Database	Details
Ala 274	-	expression tag
Gly 275	-	expression tag
Ser 276	-	expression tag
Gly 497	-	expression tag
Asn 498	-	expression tag
Ser 499	-	expression tag
His 500	-	expression tag
His 501	-	expression tag
His 502	-	expression tag
His 503	-	expression tag
His 504	-	expression tag
His 505	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	74058.5
Non-Polymers*	Number of molecules	5
	Total formula weight	424.3
All*	Total formula weight	74482.8

*Water molecules are not included.