4ZE1
Saccharomyces cerevisiae CYP51 Y140F mutant complexed with posaconazole in the active site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lanosterol 14-alpha demethylase | polymer | 539 | 61869.2 | 1 | UniProt (A6ZSR0) Pfam (PF00067) | Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) | |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C (A) | POSACONAZOLE | non-polymer | 700.8 | 1 | Chemie (X2N) | |||
| 4 | D (A) | water | water | 18.0 | 139 | Chemie (HOH) |
Sequence modifications
A: 1 - 530 (UniProt: A6ZSR0)
| PDB | External Database | Details |
|---|---|---|
| Phe 140 | Tyr 140 | engineered mutation |
| Gly 531 | - | expression tag |
| Gly 532 | - | expression tag |
| Arg 533 | - | expression tag |
| His 534 | - | expression tag |
| His 535 | - | expression tag |
| His 536 | - | expression tag |
| His 537 | - | expression tag |
| His 538 | - | expression tag |
| His 539 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 61869.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1317.3 | |
| All* | Total formula weight | 63186.5 |
