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4ZE1

Saccharomyces cerevisiae CYP51 Y140F mutant complexed with posaconazole in the active site

Functional Information from GO Data
ChainGOidnamespacecontents
A0004497molecular_functionmonooxygenase activity
A0005506molecular_functioniron ion binding
A0006696biological_processergosterol biosynthetic process
A0008168molecular_functionmethyltransferase activity
A0016020cellular_componentmembrane
A0016126biological_processsterol biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0020037molecular_functionheme binding
A0032259biological_processmethylation
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues20
Detailsbinding site for residue HEM A 601
ChainResidue
APHE113
APRO379
ALEU383
AARG385
APRO462
APHE463
AGLY464
AHIS468
ACYS470
AGLY472
AX2N602
ATYR126
AHOH864
APHE140
ALEU147
ALYS151
AVAL311
AGLY315
ATHR318
ALEU374

site_idAC2
Number of Residues19
Detailsbinding site for residue X2N A 602
ChainResidue
AALA69
AVAL70
ATYR72
AGLY73
AMET74
ATYR126
APHE134
APHE236
AGLY310
AGLY314
ALEU380
AHIS381
ASER382
APHE384
ATHR507
ASER508
AMET509
AHEM601
AHOH911

Functional Information from PROSITE/UniProt
site_idPS00086
Number of Residues10
DetailsCYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGgGRHRCIG
ChainResidueDetails
APHE463-GLY472

224201

PDB entries from 2024-08-28

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