4Z83
PKAB3 in complex with pyrrolidine inhibitor 47a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | E | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 350 | 40697.4 | 1 | UniProt (P00517) Pfam (PF00069) In PDB | Bos taurus (Bovine) | PKA C-alpha |
| 2 | I | cAMP-dependent protein kinase inhibitor alpha | polymer | 20 | 2226.4 | 1 | UniProt (P61925) In PDB | Homo sapiens | PKI-alpha,cAMP-dependent protein kinase inhibitor,muscle/brain isoform |
| 3 | E | 7-{(3S,4R)-4-[(5-bromothiophen-2-yl)carbonyl]pyrrolidin-3-yl}quinazolin-4(3H)-one | non-polymer | 404.3 | 2 | Chemie (4L7) | |||
| 4 | water | water | 18.0 | 375 | Chemie (HOH) |
Sequence modifications
E: 1 - 350 (UniProt: P00517)
| PDB | External Database | Details |
|---|---|---|
| Ala 123 | Val 124 | engineered mutation |
| Met 173 | Leu 174 | engineered mutation |
| Lys 181 | Gln 182 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42923.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 808.6 | |
| All* | Total formula weight | 43732.4 |
