4Z7I
Crystal structure of insulin regulated aminopeptidase in complex with ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Leucyl-cystinyl aminopeptidase | polymer | 912 | 104234.8 | 2 | UniProt (Q9UIQ6) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) | Homo sapiens (Human) | Cystinyl aminopeptidase,Insulin-regulated membrane aminopeptidase,Insulin-responsive aminopeptidase,IRAP,Oxytocinase,OTase,Placental leucine aminopeptidase,P-LAP |
| 2 | C, D (C, D) | DG025 transition-state analogue enzyme inhibitor | polymer | 10 | 1329.5 | 2 | synthetic construct | ||
| 3 | E, F, H, I, J (E, F, H, I, J) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 4 | G (G) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
| 5 | K, S (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | AA, L, M, N, O... (B, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 15 | Chemie (NAG) | |||
| 7 | BA, CA, DA (A, B, C) | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
A, B: 155 - 1025 (UniProt: Q9UIQ6)
| PDB | External Database | Details |
|---|---|---|
| Met 124 | - | initiating methionine |
| Gly 125 | - | expression tag |
| Ile 126 | - | expression tag |
| Leu 127 | - | expression tag |
| Pro 128 | - | expression tag |
| Ser 129 | - | expression tag |
| Pro 130 | - | expression tag |
| Gly 131 | - | expression tag |
| Met 132 | - | expression tag |
| Pro 133 | - | expression tag |
| Ala 134 | - | expression tag |
| Leu 135 | - | expression tag |
| Leu 136 | - | expression tag |
| Ser 137 | - | expression tag |
| Leu 138 | - | expression tag |
| Val 139 | - | expression tag |
| Ser 140 | - | expression tag |
| Leu 141 | - | expression tag |
| Leu 142 | - | expression tag |
| Ser 143 | - | expression tag |
| Val 144 | - | expression tag |
| Leu 145 | - | expression tag |
| Leu 146 | - | expression tag |
| Met 147 | - | expression tag |
| Gly 148 | - | expression tag |
| Cys 149 | - | expression tag |
| Val 150 | - | expression tag |
| Ala 151 | - | expression tag |
| Glu 152 | - | expression tag |
| Thr 153 | - | expression tag |
| Gly 154 | - | expression tag |
| Arg 1026 | - | expression tag |
| Thr 1027 | - | expression tag |
| Glu 1028 | - | expression tag |
| Thr 1029 | - | expression tag |
| Ser 1030 | - | expression tag |
| Gln 1031 | - | expression tag |
| Val 1032 | - | expression tag |
| Ala 1033 | - | expression tag |
| Pro 1034 | - | expression tag |
| Ala 1035 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 211128.7 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 2708.5 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 3448.9 | |
| All* | Total formula weight | 217286.1 |
