4Z7I
Crystal structure of insulin regulated aminopeptidase in complex with ligand
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Leucyl-cystinyl aminopeptidase | polymer | 912 | 104234.8 | 2 | UniProt (Q9UIQ6) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) In PDB | Homo sapiens (Human) | Cystinyl aminopeptidase,Insulin-regulated membrane aminopeptidase,Insulin-responsive aminopeptidase,IRAP,Oxytocinase,OTase,Placental leucine aminopeptidase,P-LAP |
2 | C, D | DG025 transition-state analogue enzyme inhibitor | polymer | 10 | 1329.5 | 2 | synthetic construct | ||
3 | E, F, H, I, J | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
4 | G | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
5 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
6 | B, A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 15 | Chemie (NAG) | |||
7 | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
A, B: 155 - 1025 (UniProt: Q9UIQ6)
PDB | External Database | Details |
---|---|---|
Met 124 | - | initiating methionine |
Gly 125 | - | expression tag |
Ile 126 | - | expression tag |
Leu 127 | - | expression tag |
Pro 128 | - | expression tag |
Ser 129 | - | expression tag |
Pro 130 | - | expression tag |
Gly 131 | - | expression tag |
Met 132 | - | expression tag |
Pro 133 | - | expression tag |
Ala 134 | - | expression tag |
Leu 135 | - | expression tag |
Leu 136 | - | expression tag |
Ser 137 | - | expression tag |
Leu 138 | - | expression tag |
Val 139 | - | expression tag |
Ser 140 | - | expression tag |
Leu 141 | - | expression tag |
Leu 142 | - | expression tag |
Ser 143 | - | expression tag |
Val 144 | - | expression tag |
Leu 145 | - | expression tag |
Leu 146 | - | expression tag |
Met 147 | - | expression tag |
Gly 148 | - | expression tag |
Cys 149 | - | expression tag |
Val 150 | - | expression tag |
Ala 151 | - | expression tag |
Glu 152 | - | expression tag |
Thr 153 | - | expression tag |
Gly 154 | - | expression tag |
Arg 1026 | - | expression tag |
Thr 1027 | - | expression tag |
Glu 1028 | - | expression tag |
Thr 1029 | - | expression tag |
Ser 1030 | - | expression tag |
Gln 1031 | - | expression tag |
Val 1032 | - | expression tag |
Ala 1033 | - | expression tag |
Pro 1034 | - | expression tag |
Ala 1035 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 211128.7 | |
Branched | Number of molecules | 6 |
Total formula weight | 2708.5 | |
Non-Polymers* | Number of molecules | 17 |
Total formula weight | 3448.9 | |
All* | Total formula weight | 217286.1 |