4Z6H

Crystal structure of BRD9 bromodomain in complex with a valerolactam quinolone ligand

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Bromodomain-containing protein 9	polymer	123	14249.8	2	UniProt (Q9H8M2) Pfam (PF00439)	Homo sapiens (Human)	Rhabdomyosarcoma antigen MU-RMS-40.8
2	C, D (A, B)	1,4-dimethyl-7-(2-oxopiperidin-1-yl)quinolin-2(1H)-one	non-polymer		270.3	2	Chemie (4L2)
3	E, F (A, B)	water	water		18.0	68	Chemie (HOH)

Sequence modifications

A, B: 14 - 134 (UniProt: Q9H8M2)

PDB	External Database	Details
Ser 12	-	expression tag
Met 13	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	28499.5
Non-Polymers*	Number of molecules	2
	Total formula weight	540.7
All*	Total formula weight	29040.2

*Water molecules are not included.