4Z6E
Structure of human DNA polymerase beta 279NA mutant complexed with G in the template base paired with incoming non-hydrolyzable TTP and MANGANESE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (T) | DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3') | polymer | 16 | 4844.1 | 1 | Homo sapiens | ||
| 2 | B (P) | DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3') | polymer | 10 | 3085.0 | 1 | Homo sapiens | ||
| 3 | C (D) | DNA (5'-D(P*GP*TP*CP*GP*G)-3') | polymer | 5 | 1536.0 | 1 | Homo sapiens | ||
| 4 | D (A) | DNA polymerase beta | polymer | 335 | 38198.6 | 1 | UniProt (P06746) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791) | Homo sapiens (Human) | |
| 5 | E, H (P, A) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 6 | F, G (P, D) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 7 | I (A) | 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine | non-polymer | 481.2 | 1 | Chemie (1FZ) | |||
| 8 | J, K, L, M (T, P, D, A) | water | water | 18.0 | 70 | Chemie (HOH) |
Sequence modifications
A: 1 - 335 (UniProt: P06746)
| PDB | External Database | Details |
|---|---|---|
| Ala 279 | Asn 279 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 47663.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 637.0 | |
| All* | Total formula weight | 48300.9 |
