4Z4P

Structure of the MLL4 SET Domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Histone-lysine N-methyltransferase 2D	polymer	166	19704.4	1	UniProt (O14686) Pfam (PF00856)	Homo sapiens (Human)	Lysine N-methyltransferase 2D,ALL1-related protein,Myeloid/lymphoid or mixed-lineage leukemia protein 2
2	B (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
3	C (A)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	1	Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (25210495) PubChem (13792) PubChem (177678424) PubChem (44361184) PubChem (21125603) PubChem (46936206) PubChem (50989525) PubChem (25203782) PubChem (51380914) PubChem (52224398) PubChem (189149) PubChem (57544532) PubChem (439155) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (52224400) PubChem (5284331) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (71170554) PubChem (13231890) PubChem (164157219) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525)
4	D (A)	water	water		18.0	60	Chemie (HOH)

Sequence modifications

A: 5382 - 5536 (UniProt: O14686)

PDB	External Database	Details
Met 5379	-	initiating methionine
Thr 5380	-	expression tag
Leu 5381	-	expression tag
Glu 5522	Lys 5525	engineered mutation
Lys 5537	-	expression tag
Gly 5538	-	expression tag
His 5539	-	expression tag
His 5540	-	expression tag
His 5541	-	expression tag
His 5542	-	expression tag
His 5543	-	expression tag
His 5544	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	19704.4
Non-Polymers*	Number of molecules	2
	Total formula weight	449.8
All*	Total formula weight	20154.2

*Water molecules are not included.