4Z4E
Human Argonaute2 Bound to t1-U Target RNA
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Protein argonaute-2 | polymer | 859 | 97378.2 | 1 | UniProt (Q9UKV8) Pfam (PF16486) Pfam (PF08699) Pfam (PF02170) Pfam (PF16488) Pfam (PF16487) Pfam (PF02171) In PDB | Homo sapiens (Human) | hAgo2,Argonaute RISC catalytic component 2,Eukaryotic translation initiation factor 2C 2,eIF2C 2,PAZ Piwi domain protein,PPD,Protein slicer |
2 | B | RNA (5'-R(P*UP*UP*CP*AP*CP*AP*UP*UP*GP*CP*CP*CP*AP*AP*GP*UP*CP*UP*U)-3') | polymer | 21 | 6547.9 | 1 | synthetic construct | ||
3 | D | RNA (5'-R(*CP*AP*AP*UP*GP*UP*GP*AP*U)-3') | polymer | 11 | 3515.2 | 1 | synthetic construct | ||
4 | A, B, D | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
5 | A | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 2 | Chemie (IPA) | |||
6 | A | PHENOL | non-polymer | 94.1 | 4 | Chemie (IPH) | |||
7 | A | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
8 | water | water | 18.0 | 533 | Chemie (HOH) |
Sequence modifications
A: 1 - 859 (UniProt: Q9UKV8)
PDB | External Database | Details |
---|---|---|
Asp 387 | Ser 387 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 107441.2 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 664.5 | |
All* | Total formula weight | 108105.7 |