4Z2C
Quinolone(Moxifloxacin)-DNA cleavage complex of gyrase from S. pneumoniae
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | DNA gyrase subunit A | polymer | 499 | 56747.3 | 2 | UniProt (Q9R867) Pfam (PF00521) UniProt (by SIFTS) (Q8DPM2) | Streptococcus pneumoniae | |
| 2 | B, D (C, D) | DNA gyrase subunit B | polymer | 269 | 30286.2 | 2 | UniProt (Q59957) Pfam (PF01751) Pfam (PF00986) UniProt (by SIFTS) (P0A4M0) | Streptococcus pneumoniae | |
| 3 | E, H (E, G) | Symmetrized E-site DNA | polymer | 15 | 4590.0 | 2 | Escherichia coli | ||
| 4 | F, G (F, H) | Symmetrized E-site DNA | polymer | 19 | 5821.8 | 2 | Escherichia coli | ||
| 5 | I, J (F, H) | 1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | non-polymer | 401.4 | 2 | Chemie (MFX) | |||
| 6 | K, L (H, G) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 7 | M, N, O (A, B, F) | water | water | 18.0 | 9 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 493 (UniProt: Q9R867)
C, D: 404 - 648 (UniProt: Q59957)
| PDB | External Database | Details |
|---|---|---|
| His 494 | - | expression tag |
| His 495 | - | expression tag |
| His 496 | - | expression tag |
| His 497 | - | expression tag |
| His 498 | - | expression tag |
| His 499 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 380 | - | initiating methionine |
| Gly 381 | - | expression tag |
| His 382 | - | expression tag |
| His 383 | - | expression tag |
| His 384 | - | expression tag |
| His 385 | - | expression tag |
| His 386 | - | expression tag |
| His 387 | - | expression tag |
| His 388 | - | expression tag |
| His 389 | - | expression tag |
| His 390 | - | expression tag |
| His 391 | - | expression tag |
| Ser 392 | - | expression tag |
| Ser 393 | - | expression tag |
| Gly 394 | - | expression tag |
| His 395 | - | expression tag |
| Ile 396 | - | expression tag |
| Asp 397 | - | expression tag |
| Asp 398 | - | expression tag |
| Asp 399 | - | expression tag |
| Asp 400 | - | expression tag |
| Lys 401 | - | expression tag |
| His 402 | - | expression tag |
| Met 403 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 194890.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 851.5 | |
| All* | Total formula weight | 195742.0 |
