4Z1S
Crystal structure of the first bromodomain of human BRD4 with benzotriazolo-diazepine scaffold
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Bromodomain-containing protein 4 | polymer | 126 | 14868.1 | 2 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (Human) | Protein HUNK1 |
| 2 | A, B | 5-[(4S)-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-8-yl]pyridin-2-amine | non-polymer | 416.9 | 2 | Chemie (559) | |||
| 3 | water | water | 18.0 | 308 | Chemie (HOH) |
Sequence modifications
A, B: 42 - 166 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Gly 41 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29736.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 833.8 | |
| All* | Total formula weight | 30570.0 |
