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4Z1S

Crystal structure of the first bromodomain of human BRD4 with benzotriazolo-diazepine scaffold

Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue 559 A 201
ChainResidue
ATRP81
APRO82
APHE83
ALYS91
ALEU92
ALEU94
AASN140
AILE146
AHOH312

site_idAC2
Number of Residues12
Detailsbinding site for residue 559 B 201
ChainResidue
AHIS77
APHE79
AASP145
BTRP81
BPRO82
BPHE83
BLEU92
BLEU94
BASN140
BILE146
BHOH314
BHOH403

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues212
DetailsDomain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsSite: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

244349

PDB entries from 2025-11-05

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