4Z0L
The murine cyclooxygenase-2 complexed with a nido-dicarbaborate-containing indomethacin derivative
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Prostaglandin G/H synthase 2 | polymer | 587 | 67332.7 | 4 | UniProt (Q05769) Pfam (PF00008) Pfam (PF03098) | Mus musculus (Mouse) | Cyclooxygenase-2,COX-2,Glucocorticoid-regulated inflammatory cyclooxygenase,Gripghs,Macrophage activation-associated marker protein P71/73,PES-2,PHS II,Prostaglandin H2 synthase 2,PGHS-2,Prostaglandin-endoperoxide synthase 2,TIS10 protein |
| 2 | E, F, G, H (E, F, G, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 3 | BA, I, O, U (D, A, B, C) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 4 | CA, DA, J, K, P... (D, A, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
| 5 | EA, L, R, X (D, A, B, C) | (R)-7-{[5-methoxy-2-methyl-3-(methoxycarbonylmethyl)-1H-indolyl]carbonyl}-7,8-dicarba-nido-dodeca-hydroundecaborate | non-polymer | 381.6 | 4 | Chemie (4LA) | |||
| 6 | FA, M, S, Y (D, A, B, C) | (S)-7-{[5-methoxy-2-methyl-3-(methoxycarbonylmethyl)-1H-indolyl]carbonyl}-7,8-dicarba-nido-dodeca-hydroundecaborate | non-polymer | 381.6 | 4 | Chemie (N1B) | |||
| 7 | AA, GA, N, T, Z (C, D, A, B) | octyl beta-D-glucopyranoside | non-polymer | 292.4 | 5 | Chemie (BOG) | |||
| 8 | HA, IA, JA, KA (A, B, C, D) | water | water | 18.0 | 652 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 269330.8 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1697.6 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 8750.1 | |
| All* | Total formula weight | 279778.6 |
