4YPE
ASH1L SET domain H2193F mutant in complex with S-adenosyl methionine (SAM)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone-lysine N-methyltransferase ASH1L | polymer | 226 | 26025.5 | 2 | UniProt (Q9NR48) Pfam (PF17907) Pfam (PF00856) | Homo sapiens (Human) | ASH1-like protein,huASH1,Absent small and homeotic disks protein 1 homolog,Lysine N-methyltransferase 2H |
| 2 | C, D, E, G, H... (A, B) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 3 | F, J (A, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) PubChem (5136) PubChem (34755) PubChem (58633578) PubChem (60038769) PubChem (73897310) PubChem (58766358) PubChem (87224684) PubChem (131697735) PubChem (9865603) PubChem (145712080) PubChem (12312798) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094) | |||
| 4 | K, L (A, B) | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A, B: 2069 - 2288 (UniProt: Q9NR48)
| PDB | External Database | Details |
|---|---|---|
| Gly 2063 | - | expression tag |
| Ala 2064 | - | expression tag |
| Met 2065 | - | expression tag |
| Ala 2066 | - | expression tag |
| Gly 2067 | - | expression tag |
| Ser 2068 | - | expression tag |
| Phe 2193 | His 2198 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 52051.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1189.3 | |
| All* | Total formula weight | 53240.4 |
