4YPE
ASH1L SET domain H2193F mutant in complex with S-adenosyl methionine (SAM)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone-lysine N-methyltransferase ASH1L | polymer | 226 | 26025.5 | 2 | UniProt (Q9NR48) Pfam (PF17907) Pfam (PF00856) | Homo sapiens (Human) | ASH1-like protein,huASH1,Absent small and homeotic disks protein 1 homolog,Lysine N-methyltransferase 2H |
| 2 | C, D, E, G, H... (A, B) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 3 | F, J (A, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) | |||
| 4 | K, L (A, B) | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A, B: 2069 - 2288 (UniProt: Q9NR48)
| PDB | External Database | Details |
|---|---|---|
| Gly 2063 | - | expression tag |
| Ala 2064 | - | expression tag |
| Met 2065 | - | expression tag |
| Ala 2066 | - | expression tag |
| Gly 2067 | - | expression tag |
| Ser 2068 | - | expression tag |
| Phe 2193 | His 2198 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 52051.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1189.3 | |
| All* | Total formula weight | 53240.4 |
