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4YPE

ASH1L SET domain H2193F mutant in complex with S-adenosyl methionine (SAM)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0042054molecular_functionhistone methyltransferase activity
B0005634cellular_componentnucleus
B0042054molecular_functionhistone methyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 2301
ChainResidue
ACYS2220
ACYS2268
ACYS2270
ACYS2275

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN A 2302
ChainResidue
ACYS2104
ACYS2117
ACYS2122
ACYS2128

site_idAC3
Number of Residues4
Detailsbinding site for residue ZN A 2303
ChainResidue
ACYS2093
ACYS2104
ACYS2108
ACYS2091

site_idAC4
Number of Residues16
Detailsbinding site for residue SAM A 2304
ChainResidue
ALYS2150
ATRP2152
AASP2192
APHE2193
ATYR2194
AARG2214
APHE2215
AASN2217
AHIS2218
ATYR2255
AGLN2266
ALEU2267
ACYS2268
ALYS2269
AILE2279
AHOH2411

site_idAC5
Number of Residues4
Detailsbinding site for residue ZN B 2301
ChainResidue
BCYS2220
BCYS2268
BCYS2270
BCYS2275

site_idAC6
Number of Residues5
Detailsbinding site for residue ZN B 2302
ChainResidue
BCYS2104
BCYS2117
BCYS2122
BCYS2128
BZN2303

site_idAC7
Number of Residues5
Detailsbinding site for residue ZN B 2303
ChainResidue
BCYS2091
BCYS2104
BCYS2108
BCYS2117
BZN2302

site_idAC8
Number of Residues14
Detailsbinding site for residue SAM B 2304
ChainResidue
BLYS2150
BTRP2152
BASP2192
BPHE2193
BTYR2194
BARG2214
BPHE2215
BILE2216
BASN2217
BHIS2218
BTYR2255
BLEU2267
BLYS2269
BILE2279

226707

PDB entries from 2024-10-30

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