4YNE
(R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | High affinity nerve growth factor receptor | polymer | 303 | 34261.6 | 1 | UniProt (P04629) Pfam (PF07714) In PDB | Homo sapiens (Human) | Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA |
2 | A | 6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-3-(pyridin-2-yl)imidazo[1,2-b]pyridazine | non-polymer | 359.4 | 1 | Chemie (4EK) | |||
3 | A | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
5 | water | water | 18.0 | 78 | Chemie (HOH) |
Sequence modifications
A: 502 - 796 (UniProt: P04629)
PDB | External Database | Details |
---|---|---|
Gly -7 | - | expression tag |
Ala -6 | - | expression tag |
Met -5 | - | expression tag |
Gly -4 | - | expression tag |
Ser -3 | - | expression tag |
Gly -2 | - | expression tag |
Ile -1 | - | expression tag |
Arg 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34261.6 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 931.8 | |
All* | Total formula weight | 35193.4 |