4YNE
(R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | High affinity nerve growth factor receptor | polymer | 303 | 34261.6 | 1 | UniProt (P04629) Pfam (PF07714) | Homo sapiens (Human) | Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA |
| 2 | B (A) | 6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-3-(pyridin-2-yl)imidazo[1,2-b]pyridazine | non-polymer | 359.4 | 1 | Chemie (4EK) | |||
| 3 | C, D, E, F, G (A) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 4 | H (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | I (A) | water | water | 18.0 | 78 | Chemie (HOH) |
Sequence modifications
A: 502 - 796 (UniProt: P04629)
| PDB | External Database | Details |
|---|---|---|
| Gly -7 | - | expression tag |
| Ala -6 | - | expression tag |
| Met -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ile -1 | - | expression tag |
| Arg 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34261.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 931.8 | |
| All* | Total formula weight | 35193.4 |
