4YMJ
(R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NT-3 growth factor receptor | polymer | 304 | 34727.3 | 2 | UniProt (Q16288) Pfam (PF07714) | Homo sapiens (Human) | GP145-TrkC,Trk-C,Neurotrophic tyrosine kinase receptor type 3,TrkC tyrosine kinase |
| 2 | C, H (A, B) | 4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile | non-polymer | 325.4 | 2 | Chemie (4EJ) | |||
| 3 | D, E, F, I, J... (A, B) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 4 | G (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | L, M (A, B) | water | water | 18.0 | 383 | Chemie (HOH) |
Sequence modifications
A, B: 530 - 839 (UniProt: Q16288)
| PDB | External Database | Details |
|---|---|---|
| Gly -8 | - | expression tag |
| Ala -7 | - | expression tag |
| Met -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Ser -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ile -2 | - | expression tag |
| His -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69454.6 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1238.8 | |
| All* | Total formula weight | 70693.4 |
