Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue 4EJ A 901 |
| Chain | Residue |
| A | GLY545 |
| A | PHE698 |
| A | GOL902 |
| A | VAL552 |
| A | ALA570 |
| A | LYS572 |
| A | PHE617 |
| A | GLU618 |
| A | TYR619 |
| A | MET620 |
| A | LEU686 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 902 |
| Chain | Residue |
| A | LYS572 |
| A | GLU588 |
| A | LEU592 |
| A | PHE617 |
| A | GLY696 |
| A | ASP697 |
| A | PHE698 |
| A | 4EJ901 |
| A | GOL903 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 903 |
| Chain | Residue |
| A | ILE695 |
| A | GLY696 |
| A | ASP697 |
| A | GOL902 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 904 |
| Chain | Residue |
| A | ARG735 |
| A | TRP754 |
| A | TRP771 |
| A | CYS782 |
| A | ILE783 |
| A | ARG787 |
| A | VAL788 |
| A | LEU789 |
| A | TRP807 |
| A | HOH1067 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue CL A 905 |
| Chain | Residue |
| A | ARG535 |
| A | ILE538 |
| A | LEU540 |
| B | ARG535 |
| B | ILE538 |
| B | LEU540 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for residue 4EJ B 901 |
| Chain | Residue |
| B | VAL552 |
| B | ALA570 |
| B | LYS572 |
| B | PHE617 |
| B | GLU618 |
| B | TYR619 |
| B | MET620 |
| B | GLY623 |
| B | LEU686 |
| B | PHE698 |
| B | MET700 |
| B | GOL902 |
| B | HOH1048 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 902 |
| Chain | Residue |
| B | LYS572 |
| B | GLY696 |
| B | ASP697 |
| B | PHE698 |
| B | 4EJ901 |
| B | GOL904 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 903 |
| Chain | Residue |
| B | HIS599 |
| B | HIS658 |
| B | GLN662 |
| B | ASN690 |
| B | LEU691 |
| B | LEU692 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 904 |
| Chain | Residue |
| B | ILE600 |
| B | PHE675 |
| B | ILE695 |
| B | GLY696 |
| B | ASP697 |
| B | GOL902 |
| B | HOH1122 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 29 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGKVFlAecynlsptkdkml.....VAVK |
| Chain | Residue | Details |
| A | LEU544-LYS572 | |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLATRNCLV |
| Chain | Residue | Details |
| A | PHE675-VAL687 | |
| site_id | PS00239 |
| Number of Residues | 9 |
| Details | RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DVYstdYYR |
| Chain | Residue | Details |
| A | ASP703-ARG711 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | VAL687 | |
| B | VAL687 | |
| Chain | Residue | Details |
| A | VAL552 | |
| A | ALA580 | |
| B | VAL552 | |
| B | ALA580 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY727 | |
| A | MET731 | |
| A | LEU732 | |
| B | GLY727 | |
| B | MET731 | |
| B | LEU732 | |
