4YII

Structure of an APC2-UBCH10 complex reveals distinctive cullin-RING ligase mechanism for Anaphase-promoting complex/Cyclosome

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (U)	Ubiquitin-conjugating enzyme E2 C	polymer	155	17360.7	1	UniProt (O00762) Pfam (PF00179)	Homo sapiens (Human)	UbcH10,Ubiquitin carrier protein C,Ubiquitin-protein ligase C
2	B (A)	Anaphase-promoting complex subunit 2	polymer	90	10259.7	1	UniProt (Q9UJX6) Pfam (PF08672)	Homo sapiens (Human)	APC2,Cyclosome subunit 2
3	C, D (U, A)	water	water		18.0	64	Chemie (HOH)

Sequence modifications

U: 27 - 179 (UniProt: O00762)

PDB	External Database	Details
Gly 25	-	expression tag
Ser 26	-	expression tag

A: 735 - 822 (UniProt: Q9UJX6)

PDB	External Database	Details
Gly 733	-	expression tag
Ser 734	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	27620.4
All*	Total formula weight	27620.4

*Water molecules are not included.