4YIA
Structural mechanism of hormone release in thyroxine binding globulin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Thyroxine-binding globulin | polymer | 375 | 41794.1 | 1 | UniProt (P05543) Pfam (PF00079) | Homo sapiens (Human) | Serpin A7,T4-binding globulin |
| 2 | B (B) | Thyroxine-binding globulin | polymer | 34 | 3913.7 | 1 | UniProt (P05543) | Homo sapiens (Human) | Serpin A7,T4-binding globulin |
| 3 | C, H (A, B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 4 | D, E (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 5 | F, I (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | G (B) | INDOMETHACIN | non-polymer | 357.8 | 1 | Chemie (IMN) | |||
| 7 | J, K (A, B) | water | water | 18.0 | 197 | Chemie (HOH) |
Sequence modifications
A: -19 - 355 (UniProt: P05543)
| PDB | External Database | Details |
|---|---|---|
| Gly 346 | Ala 366 | see sequence details |
| Ala 347 | Val 367 | see sequence details |
| Met 348 | Pro 368 | see sequence details |
| Phe 349 | Glu 369 | see sequence details |
| Leu 350 | Val 370 | see sequence details |
| Ala 352 | Leu 372 | see sequence details |
| Ile 353 | Ser 373 | see sequence details |
| Pro 354 | Asp 374 | see sequence details |
| Arg 355 | Gln 375 | see sequence details |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 45707.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 554.8 | |
| All* | Total formula weight | 46262.6 |
