4YHJ
Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4 (GRK4)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | G protein-coupled receptor kinase 4 | polymer | 584 | 67447.0 | 2 | UniProt (P32298) Pfam (PF00615) Pfam (PF00069) | Homo sapiens (Human) | G protein-coupled receptor kinase GRK4,ITI1 |
| 2 | C, D (A, B) | AMP PHOSPHORAMIDATE | non-polymer | 426.2 | 2 | Chemie (AN2) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 123 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 578 (UniProt: P32298)
| PDB | External Database | Details |
|---|---|---|
| Ser 563 | Cys 563 | engineered mutation |
| Ser 578 | Cys 578 | engineered mutation |
| Glu 579 | - | expression tag |
| Asn 580 | - | expression tag |
| Leu 581 | - | expression tag |
| Tyr 582 | - | expression tag |
| Phe 583 | - | expression tag |
| Gln 584 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 134894.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 852.4 | |
| All* | Total formula weight | 135746.5 |
