4YHJ
Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4 (GRK4)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004703 | molecular_function | G protein-coupled receptor kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005938 | cellular_component | cell cortex |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007165 | biological_process | signal transduction |
| A | 0008277 | biological_process | regulation of G protein-coupled receptor signaling pathway |
| A | 0009966 | biological_process | regulation of signal transduction |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0022400 | biological_process | regulation of opsin-mediated signaling pathway |
| A | 0031623 | biological_process | receptor internalization |
| A | 0050254 | molecular_function | rhodopsin kinase activity |
| A | 0097381 | cellular_component | photoreceptor disc membrane |
| A | 0120238 | cellular_component | sperm glycocalyx |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0004703 | molecular_function | G protein-coupled receptor kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005938 | cellular_component | cell cortex |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007165 | biological_process | signal transduction |
| B | 0008277 | biological_process | regulation of G protein-coupled receptor signaling pathway |
| B | 0009966 | biological_process | regulation of signal transduction |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0022400 | biological_process | regulation of opsin-mediated signaling pathway |
| B | 0031623 | biological_process | receptor internalization |
| B | 0050254 | molecular_function | rhodopsin kinase activity |
| B | 0097381 | cellular_component | photoreceptor disc membrane |
| B | 0120238 | cellular_component | sperm glycocalyx |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue AN2 A 601 |
| Chain | Residue |
| A | GLY194 |
| A | GLY197 |
| A | VAL201 |
| A | ALA214 |
| A | THR265 |
| A | MET267 |
| A | ASP330 |
| A | HOH746 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue AN2 B 601 |
| Chain | Residue |
| B | LYS195 |
| B | GLY196 |
| B | GLY197 |
| B | VAL201 |
| B | ALA214 |
| B | LYS216 |
| B | THR265 |
| B | MET267 |
| B | ASP330 |
| B | HOH738 |
| B | GLY194 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 33 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGGFGEVCaCqvratgkmyackklqkk.RIKK |
| Chain | Residue | Details |
| A | LEU193-LYS225 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvYrDLKpeNILL |
| Chain | Residue | Details |
| A | ILE308-LEU320 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 240 |
| Details | Domain: {"description":"RGS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00171","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 524 |
| Details | Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 65 |
| Details | Domain: {"description":"AGC-kinase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00618","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P70507","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
