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4YHJ

Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4 (GRK4)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004703molecular_functionG protein-coupled receptor kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0006468biological_processprotein phosphorylation
A0007165biological_processsignal transduction
A0008277biological_processregulation of G protein-coupled receptor signaling pathway
A0009966biological_processregulation of signal transduction
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0022400biological_processregulation of opsin-mediated signaling pathway
A0031623biological_processreceptor internalization
A0050254molecular_functionrhodopsin kinase activity
A0097381cellular_componentphotoreceptor disc membrane
B0000166molecular_functionnucleotide binding
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004703molecular_functionG protein-coupled receptor kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005938cellular_componentcell cortex
B0006468biological_processprotein phosphorylation
B0007165biological_processsignal transduction
B0008277biological_processregulation of G protein-coupled receptor signaling pathway
B0009966biological_processregulation of signal transduction
B0016301molecular_functionkinase activity
B0016740molecular_functiontransferase activity
B0022400biological_processregulation of opsin-mediated signaling pathway
B0031623biological_processreceptor internalization
B0050254molecular_functionrhodopsin kinase activity
B0097381cellular_componentphotoreceptor disc membrane
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue AN2 A 601
ChainResidue
AGLY194
AGLY197
AVAL201
AALA214
ATHR265
AMET267
AASP330
AHOH746

site_idAC2
Number of Residues11
Detailsbinding site for residue AN2 B 601
ChainResidue
BLYS195
BGLY196
BGLY197
BVAL201
BALA214
BLYS216
BTHR265
BMET267
BASP330
BHOH738
BGLY194

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues33
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGGFGEVCaCqvratgkmyackklqkk.RIKK
ChainResidueDetails
ALEU193-LYS225

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvYrDLKpeNILL
ChainResidueDetails
AILE308-LEU320

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP312
BASP312

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU193
ALYS216
BLEU193
BLYS216

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22223895
ChainResidueDetails
AMET1
BMET1

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P70507
ChainResidueDetails
ASER485
BSER485

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PDB entries from 2025-07-02

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