4YHC

Crystal structure of the WD40 domain of SCAP from fission yeast

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Sterol regulatory element-binding protein cleavage-activating protein	polymer	468	52790.4	2	UniProt (O43043)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	SREBP cleavage-activating protein,SREBP cleavage-activating protein
2	C, D (A)	CITRIC ACID	non-polymer		192.1	2	Chemie (CIT)
3	E, F (A, B)	water	water		18.0	307	Chemie (HOH)

Sequence modifications

A, B: 567 - 982 (UniProt: O43043)

PDB	External Database	Details
Met 566	-	expression tag
Ser 618	Cys 618	engineered mutation
Ser 671	Cys 671	engineered mutation
Ser 680	Cys 680	engineered mutation
Ser 756	Cys 756	engineered mutation
Ser 873	Cys 873	engineered mutation
Ser 901	Cys 901	engineered mutation
Ser 920	Cys 920	engineered mutation
Ser 941	Cys 941	engineered mutation

A, B: 986 - 1054 (UniProt: O43043)

PDB	External Database	Details
Ala 983	-	linker
Gly 984	-	linker
Ser 985	-	linker
Ser 1010	Cys 1010	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	105580.9
Non-Polymers*	Number of molecules	2
	Total formula weight	384.2
All*	Total formula weight	105965.1

*Water molecules are not included.