4YH7

Crystal structure of PTPdelta ectodomain in complex with IL1RAPL1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Receptor-type tyrosine-protein phosphatase delta	polymer	841	93559.5	1	UniProt (Q64487) Pfam (PF07679) Pfam (PF13927) Pfam (PF00041) In PDB	Mus musculus (Mouse)	R-PTP-delta
2	B	Interleukin-1 receptor accessory protein-like 1	polymer	348	39816.3	1	UniProt (P59823) Pfam (PF18452) Pfam (PF00047) In PDB	Mus musculus (Mouse)	IL1RAPL-1,X-linked interleukin-1 receptor accessory protein-like 1
3	C	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	D	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
5	B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

A: 28 - 861 (UniProt: Q64487)

PDB	External Database	Details
Lys 862	-	expression tag
His 863	-	expression tag
His 864	-	expression tag
His 865	-	expression tag
His 866	-	expression tag
His 867	-	expression tag
His 868	-	expression tag

B: 19 - 352 (UniProt: P59823)

PDB	External Database	Details
Ala 12	-	expression tag
Gln 13	-	expression tag
Pro 14	-	expression tag
Ala 15	-	expression tag
Ala 16	-	expression tag
Arg 17	-	expression tag
Asp 18	-	expression tag
Lys 353	-	expression tag
His 354	-	expression tag
His 355	-	expression tag
His 356	-	expression tag
His 357	-	expression tag
His 358	-	expression tag
His 359	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	133375.7
Branched	Number of molecules	2
	Total formula weight	1335.2
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	135153.4

*Water molecules are not included.