4YDL

Crystal structure of broadly and potently neutralizing antibody C38-VRC18.02 in complex with HIV-1 clade AE strain 93TH057gp120

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (G, A)	Envelope glycoprotein gp160,Envelope glycoprotein gp160	polymer	353	39211.4	2	UniProt (Q0ED31) Pfam (PF00516)	Human immunodeficiency virus 1
2	B, E (H, B)	HEAVY CHAIN OF ANTIBODY C38-VRC18.02	polymer	226	24402.5	2		Homo sapiens (Human)
3	C, F (L, C)	LIGHT CHAIN OF ANTIBODY C38-VRC18.02	polymer	211	23291.0	2		Homo sapiens (Human)
4	AA, BA, CA, EA, G... (A, C, G, L)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	22	Chemie (NAG)
5	DA, Q (A, G)	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	2	Chemie (EPE)
6	FA, GA, S (C, L)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
7	HA, IA, JA, KA, LA... (G, H, L, A, B...)	water	water		18.0	1402	Chemie (HOH)

Sequence modifications

G, A: 44 - 123 (UniProt: Q0ED31)
G, A: 199 - 301 (UniProt: Q0ED31)

PDB	External Database	Details
Gly 124	-	linker
Gly 198	-	linker

G, A: 324 - 492 (UniProt: Q0ED31)

PDB	External Database	Details
Gly 318	-	linker
Gly 319	-	linker
Ser 320	-	linker
Gly 321	-	linker
Ser 322	-	linker
Gly 323	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	173809.9
Non-Polymers*	Number of molecules	27
	Total formula weight	5631.4
All*	Total formula weight	179441.3

*Water molecules are not included.