4YDH

The structure of human FMNL1 N-terminal domains bound to Cdc42

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Formin-like protein 1	polymer	433	49313.1	2	UniProt (O95466) Pfam (PF06371) Pfam (PF06367)	Homo sapiens (Human)	CLL-associated antigen KW-13,Leukocyte formin
2	B, D (B, D)	Cell division control protein 42 homolog	polymer	181	20028.0	2	UniProt (P60953) Pfam (PF00071)	Homo sapiens (Human)	G25K GTP-binding protein
3	E, G (B, D)	PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER	non-polymer		522.2	2	Chemie (GNP)
4	F, H (B, D)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)

Sequence modifications

A, C: 1 - 458 (UniProt: O95466)

PDB	External Database	Details
Gly -1	-	expression tag
Ala 0	-	expression tag
-	Ala 172	deletion
-	Ser 173	deletion
-	Asn 174	deletion
-	Ser 175	deletion
-	Glu 176	deletion
-	Lys 177	deletion
-	Asn 178	deletion
-	Lys 179	deletion
-	Pro 180	deletion
-	Leu 181	deletion
-	Glu 182	deletion
-	Gln 183	deletion
-	Ser 184	deletion
-	Val 185	deletion
-	Glu 186	deletion
-	Asp 187	deletion
-	Leu 188	deletion
-	Ser 189	deletion
-	Lys 190	deletion
-	Gly 191	deletion
-	Pro 192	deletion
-	Pro 193	deletion
-	Ser 194	deletion
-	Ser 195	deletion
-	Val 196	deletion
-	Pro 197	deletion
-	Lys 198	deletion
Ala 455	Pro 455	conflict

B, D: 1 - 179 (UniProt: P60953)

PDB	External Database	Details
Gly -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	138682.1
Non-Polymers*	Number of molecules	4
	Total formula weight	1093.0
All*	Total formula weight	139775.1

*Water molecules are not included.